MIR3679

Summary

MIR3679 (microRNA 3679, HGNC:38979) is a microRNA gene on chromosome 2q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500878 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38979
Approved symbol	MIR3679
Name	microRNA 3679
Location	2q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3679
Ensembl gene	ENSG00000263813
Ensembl biotype	miRNA
Entrez	100500878
RNAcentral	URS000075AC34 — miRNA, 68 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581102

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581102 — 1 exons

Exon	Start	End
ENSE00002716419	134127125	134127192

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 96.91.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	96.91	gold quality
adrenal tissue	UBERON:0018303	93.47	gold quality
kidney	UBERON:0002113	89.55	gold quality
adult mammalian kidney	UBERON:0000082	84.62	gold quality
blood	UBERON:0000178	83.42	gold quality
bone marrow	UBERON:0002371	82.17	gold quality
stomach	UBERON:0000945	81.44	gold quality
calcaneal tendon	UBERON:0003701	79.98	gold quality
liver	UBERON:0002107	78.19	gold quality
heart	UBERON:0000948	75.09	gold quality
urinary bladder	UBERON:0001255	74.90	gold quality
corpus callosum	UBERON:0002336	74.79	gold quality
monocyte	CL:0000576	74.16	gold quality
islet of Langerhans	UBERON:0000006	71.83	gold quality
tibial artery	UBERON:0007610	71.29	gold quality
tonsil	UBERON:0002372	70.97	gold quality
body of stomach	UBERON:0001161	70.13	gold quality
left adrenal gland cortex	UBERON:0035825	70.07	gold quality
heart left ventricle	UBERON:0002084	70.05	gold quality
intestine	UBERON:0000160	68.87	gold quality
endometrium	UBERON:0001295	68.84	gold quality
right atrium auricular region	UBERON:0006631	68.68	gold quality
lung	UBERON:0002048	68.54	gold quality
Ammon’s horn	UBERON:0001954	68.38	gold quality
left adrenal gland	UBERON:0001234	68.26	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.94	gold quality
colon	UBERON:0001155	67.80	gold quality
anterior cingulate cortex	UBERON:0009835	67.18	gold quality
transverse colon	UBERON:0001157	67.08	gold quality
esophagus mucosa	UBERON:0002469	67.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.69

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Salivary miR-3679-5p and miR-940 possess good discriminatory power to detect resectable pancreatic cancer. (PMID:25538087)
• Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells. (PMID:32125007)
• [Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell Proliferation]. (PMID:36224673)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.