MIR3680-1

Summary

MIR3680-1 (microRNA 3680-1, HGNC:38989) is a microRNA gene on chromosome 16p12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500917 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38989
Approved symbol	MIR3680-1
Name	microRNA 3680-1
Location	16p12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3680
Ensembl gene	ENSG00000265462
Ensembl biotype	miRNA
Entrez	100500917
RNAcentral	URS000075CE98 — ncRNA, 87 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581433

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581433 — 1 exons

Exon	Start	End
ENSE00002704270	21506049	21506135

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 79.08.

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.08	gold quality
skeletal muscle tissue	UBERON:0001134	77.79	gold quality
adrenal tissue	UBERON:0018303	76.79	gold quality
bone marrow	UBERON:0002371	76.66	gold quality
vermiform appendix	UBERON:0001154	73.26	gold quality
blood	UBERON:0000178	72.69	gold quality
muscle of leg	UBERON:0001383	71.14	gold quality
placenta	UBERON:0001987	71.09	gold quality
monocyte	CL:0000576	71.01	gold quality
gastrocnemius	UBERON:0001388	70.59	gold quality
sural nerve	UBERON:0015488	70.10	gold quality
apex of heart	UBERON:0002098	69.98	gold quality
corpus callosum	UBERON:0002336	68.90	gold quality
fundus of stomach	UBERON:0001160	68.21	gold quality
lymph node	UBERON:0000029	67.75	gold quality
smooth muscle tissue	UBERON:0001135	67.34	gold quality
liver	UBERON:0002107	67.33	gold quality
right coronary artery	UBERON:0001625	66.60	gold quality
stomach	UBERON:0000945	66.16	gold quality
heart	UBERON:0000948	66.13	gold quality
endometrium	UBERON:0001295	66.03	gold quality
heart left ventricle	UBERON:0002084	65.95	gold quality
islet of Langerhans	UBERON:0000006	65.79	gold quality
popliteal artery	UBERON:0002250	65.39	gold quality
rectum	UBERON:0001052	65.34	gold quality
tibial artery	UBERON:0007610	65.31	gold quality
left coronary artery	UBERON:0001626	65.17	gold quality
body of stomach	UBERON:0001161	65.04	gold quality
right atrium auricular region	UBERON:0006631	65.04	gold quality
tonsil	UBERON:0002372	65.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• In this study, miR-3680-5p was associated with parathyroid hormone regulation (PMID:28152049)
• Downregulation of miR-3680-3p inhibits the progression of osteoarthritis via targeting OGG1. (PMID:35092863)

Cross-species orthologs

0 orthologs

Paralogs (1): MIR3680-2 (ENSG00000266758)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.