MIR3681

Summary

MIR3681 (microRNA 3681, HGNC:38994) is a microRNA gene on chromosome 2p24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500884 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38994
Approved symbol	MIR3681
Name	microRNA 3681
Location	2p24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3681
Ensembl gene	ENSG00000264089
Ensembl biotype	miRNA
Entrez	100500884
RNAcentral	URS000075B2FC — ncRNA, 72 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580089

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580089 — 1 exons

Exon	Start	End
ENSE00002717944	12199130	12199201

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 80.99.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
caudate nucleus	UBERON:0001873	80.99	gold quality
blood	UBERON:0000178	71.39	gold quality
putamen	UBERON:0001874	66.49	gold quality
tonsil	UBERON:0002372	66.45	gold quality
nucleus accumbens	UBERON:0001882	62.31	gold quality
pituitary gland	UBERON:0000007	61.37	gold quality
omental fat pad	UBERON:0010414	59.99	gold quality
right frontal lobe	UBERON:0002810	59.72	gold quality
left ovary	UBERON:0002119	58.09	gold quality
Brodmann (1909) area 9	UBERON:0013540	57.14	gold quality
left testis	UBERON:0004533	41.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Enhancer Function of MicroRNA-3681 Derived from Long Terminal Repeats Represses the Activity of Variable Number Tandem Repeats in the 3’ UTR of SHISA7. (PMID:32655015)
• Long-chain non-coding RNA LINC01554 promotes NGFR expression and inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma by binding to microRNA-3681-3p. (PMID:33378013)
• Long non-coding RNA (lncRNA) HOXD-AS2 promotes glioblastoma cell proliferation, migration and invasion by regulating the miR-3681-5p/MALT1 signaling pathway. (PMID:34802389)
• ETV4 mediated lncRNA C2CD4D-AS1 overexpression contributes to the malignant phenotype of lung adenocarcinoma cells via miR-3681-3p/NEK2 axis. (PMID:34850664)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.