MIR3682

Summary

MIR3682 (microRNA 3682, HGNC:38916) is a microRNA gene on chromosome 2p16.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500850 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38916
Approved symbol	MIR3682
Name	microRNA 3682
Location	2p16.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3682
Ensembl gene	ENSG00000265452
Ensembl biotype	miRNA
Entrez	100500850
RNAcentral	URS000075A917 — ncRNA, 84 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581338

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581338 — 1 exons

Exon	Start	End
ENSE00002725182	53849122	53849205

Expression profiles

Bgee: expression breadth ubiquitous, 213 present calls, max score 98.61.

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	98.61	gold quality
Brodmann (1909) area 9	UBERON:0013540	97.88	gold quality
amygdala	UBERON:0001876	97.34	gold quality
caudate nucleus	UBERON:0001873	97.20	gold quality
nucleus accumbens	UBERON:0001882	97.20	gold quality
putamen	UBERON:0001874	97.12	gold quality
hypothalamus	UBERON:0001898	96.98	gold quality
anterior cingulate cortex	UBERON:0009835	96.86	gold quality
right frontal lobe	UBERON:0002810	96.51	gold quality
substantia nigra	UBERON:0002038	95.38	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	95.14	gold quality
granulocyte	CL:0000094	94.89	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	94.69	gold quality
midbrain	UBERON:0001891	94.42	gold quality
spinal cord	UBERON:0002240	94.33	gold quality
adenohypophysis	UBERON:0002196	93.85	gold quality
forebrain	UBERON:0001890	93.63	gold quality
brain	UBERON:0000955	93.31	gold quality
right hemisphere of cerebellum	UBERON:0014890	93.28	gold quality
lateral globus pallidus	UBERON:0002476	93.24	gold quality
Ammon’s horn	UBERON:0001954	93.16	gold quality
neocortex	UBERON:0001950	93.06	gold quality
cerebellar hemisphere	UBERON:0002245	92.80	gold quality
cerebral cortex	UBERON:0000956	92.68	gold quality
temporal lobe	UBERON:0001871	92.34	gold quality
cerebellum	UBERON:0002037	91.80	gold quality
frontal cortex	UBERON:0001870	91.29	gold quality
pituitary gland	UBERON:0000007	91.01	gold quality
primary visual cortex	UBERON:0002436	90.74	gold quality
adrenal tissue	UBERON:0018303	90.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.06

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• A novel prognostic mRNA/miRNA signature for esophageal cancer and its immune landscape in cancer progression. (PMID:33463006)
• BMI1 activates P-glycoprotein via transcription repression of miR-3682-3p and enhances chemoresistance of bladder cancer cell. (PMID:34270461)
• MiR-3682 promotes the progression of hepatocellular carcinoma (HCC) via inactivating AMPK signaling by targeting ADRA1A. (PMID:34706275)
• [High expression of miR-3682-3p is an unfavorable prognostic factor of hepatocellular carcinoma]. (PMID:35012923)
• miR-3682-3p Activated by c-Myc Aggravates the Migration and Stemness in Hepatocellular Carcinoma Cells by Regulating PTEN/PI3K/AKT/beta-Catenin Signaling. (PMID:36366818)
• Celestial Insights: Unraveling the Role of miR-3682-3p in Hepatocellular Carcinoma. (PMID:38334941)
• MiR-3682-3p promotes esophageal cancer progression by targeting FHL1 and activating the Wnt/beta-catenin signaling pathway. (PMID:38565413)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.