MIR3683

Summary

MIR3683 (microRNA 3683, HGNC:38999) is a microRNA gene on chromosome 7p22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500886 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38999
Approved symbol	MIR3683
Name	microRNA 3683
Location	7p22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3683
Ensembl gene	ENSG00000266287
Ensembl biotype	miRNA
Entrez	100500886
RNAcentral	URS000075C564 — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580847

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580847 — 1 exons

Exon	Start	End
ENSE00002708226	7066964	7067045

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 80.27.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	80.27	gold quality
monocyte	CL:0000576	78.80	gold quality
intestine	UBERON:0000160	76.41	gold quality
heart	UBERON:0000948	76.22	gold quality
body of stomach	UBERON:0001161	71.34	gold quality
granulocyte	CL:0000094	68.16	gold quality
stomach	UBERON:0000945	68.00	gold quality
right frontal lobe	UBERON:0002810	66.76	gold quality
transverse colon	UBERON:0001157	66.16	gold quality
colon	UBERON:0001155	65.40	gold quality
right ovary	UBERON:0002118	64.38	gold quality
skin of leg	UBERON:0001511	62.65	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.25	gold quality
metanephros cortex	UBERON:0010533	59.55	gold quality
right testis	UBERON:0004534	54.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.