MIR3684

Summary

MIR3684 (microRNA 3684, HGNC:38950) is a microRNA gene on chromosome 4q23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500867 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38950
Approved symbol	MIR3684
Name	microRNA 3684
Location	4q23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3684
Ensembl gene	ENSG00000265213
Ensembl biotype	miRNA
Entrez	100500867
RNAcentral	URS000075A5AF — miRNA, 74 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579779

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579779 — 1 exons

Exon	Start	End
ENSE00002693779	98997387	98997460

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 81.60.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	81.60	gold quality
calcaneal tendon	UBERON:0003701	79.97	gold quality
adrenal tissue	UBERON:0018303	77.20	gold quality
blood	UBERON:0000178	76.61	gold quality
endometrium	UBERON:0001295	76.08	gold quality
kidney	UBERON:0002113	76.00	gold quality
liver	UBERON:0002107	75.22	gold quality
stomach	UBERON:0000945	74.75	gold quality
heart	UBERON:0000948	74.27	gold quality
monocyte	CL:0000576	72.55	gold quality
caudate nucleus	UBERON:0001873	72.15	gold quality
right atrium auricular region	UBERON:0006631	72.04	gold quality
islet of Langerhans	UBERON:0000006	71.81	gold quality
gastrocnemius	UBERON:0001388	70.53	gold quality
body of stomach	UBERON:0001161	70.16	gold quality
body of pancreas	UBERON:0001150	69.27	gold quality
lung	UBERON:0002048	68.88	gold quality
tibial artery	UBERON:0007610	68.64	gold quality
heart left ventricle	UBERON:0002084	68.60	gold quality
colon	UBERON:0001155	68.05	gold quality
Ammon’s horn	UBERON:0001954	68.00	gold quality
intestine	UBERON:0000160	67.73	gold quality
transverse colon	UBERON:0001157	67.60	gold quality
hypothalamus	UBERON:0001898	67.09	gold quality
right lobe of liver	UBERON:0001114	67.06	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.31	gold quality
thoracic aorta	UBERON:0001515	65.83	gold quality
ascending aorta	UBERON:0001496	65.76	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.64	gold quality
amygdala	UBERON:0001876	65.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.