MIR3685

Summary

MIR3685 (microRNA 3685, HGNC:38886) is a microRNA gene on chromosome 12q22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500802 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38886
Approved symbol	MIR3685
Name	microRNA 3685
Location	12q22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3685
Ensembl gene	ENSG00000265917
Ensembl biotype	miRNA
Entrez	100500802
RNAcentral	URS000075A777 — ncRNA, 62 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579373

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579373 — 1 exons

Exon	Start	End
ENSE00002710101	95309923	95309984

Expression profiles

Bgee: expression breadth ubiquitous, 198 present calls, max score 95.80.

Top tissues by expression

228 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of thyroid gland	UBERON:0001119	95.80	gold quality
left lobe of thyroid gland	UBERON:0001120	95.41	gold quality
rectum	UBERON:0001052	95.12	gold quality
cerebellar hemisphere	UBERON:0002245	95.08	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.74	gold quality
thyroid gland	UBERON:0002046	94.35	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.36	gold quality
cerebellum	UBERON:0002037	93.20	gold quality
body of uterus	UBERON:0009853	93.18	gold quality
epithelial cell of pancreas	CL:0000083	92.83	gold quality
metanephros cortex	UBERON:0010533	92.61	gold quality
adrenal tissue	UBERON:0018303	92.42	gold quality
left ovary	UBERON:0002119	92.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	92.33	gold quality
popliteal artery	UBERON:0002250	92.32	gold quality
tibial artery	UBERON:0007610	92.31	gold quality
ascending aorta	UBERON:0001496	92.19	gold quality
thoracic aorta	UBERON:0001515	92.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	92.15	gold quality
right ovary	UBERON:0002118	92.13	gold quality
aorta	UBERON:0000947	92.07	gold quality
descending thoracic aorta	UBERON:0002345	91.97	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	91.84	gold quality
lower esophagus muscularis layer	UBERON:0035833	91.78	gold quality
lower esophagus	UBERON:0013473	91.72	gold quality
tibial nerve	UBERON:0001323	91.54	gold quality
gastrocnemius	UBERON:0001388	91.20	gold quality
smooth muscle tissue	UBERON:0001135	90.78	gold quality
muscle of leg	UBERON:0001383	90.71	gold quality
right coronary artery	UBERON:0001625	90.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.70

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.