MIR3686

Summary

MIR3686 (microRNA 3686, HGNC:38887) is a microRNA gene on chromosome 8q24.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500839 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38887
Approved symbol	MIR3686
Name	microRNA 3686
Location	8q24.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3686
Ensembl gene	ENSG00000263763
Ensembl biotype	miRNA
Entrez	100500839
RNAcentral	URS000075EB23 — miRNA, 86 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577904

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577904 — 1 exons

Exon	Start	End
ENSE00002732164	129484057	129484142

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 81.64.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
intestine	UBERON:0000160	81.64	gold quality
blood	UBERON:0000178	80.42	gold quality
lung	UBERON:0002048	74.02	gold quality
liver	UBERON:0002107	66.97	gold quality
right frontal lobe	UBERON:0002810	60.18	gold quality
spleen	UBERON:0002106	53.89	gold quality
thyroid gland	UBERON:0002046	53.67	gold quality
stomach	UBERON:0000945	49.91	gold quality
left testis	UBERON:0004533	42.09	gold quality
right testis	UBERON:0004534	34.01	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• our results indicated that mir3686 could target PLK1 to inhibit the cell proliferation in pancreas cancer derived cell line and mir3686 could be a new therapeutic target for pancreas cancer treatment. (PMID:26090465)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.