MIR3689A

Summary

MIR3689A (microRNA 3689a, HGNC:38904) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500846 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38904
Approved symbol	MIR3689A
Name	microRNA 3689a
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3689a
Ensembl gene	ENSG00000265872
Ensembl biotype	miRNA
Entrez	100500846
RNAcentral	URS000075D8AE — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578854

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578854 — 1 exons

Exon	Start	End
ENSE00002686245	134849487	134849564

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 90.88.

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	90.88	gold quality
myometrium	UBERON:0001296	77.01	gold quality
stomach	UBERON:0000945	75.74	gold quality
calcaneal tendon	UBERON:0003701	72.60	gold quality
heart	UBERON:0000948	71.07	gold quality
tibial nerve	UBERON:0001323	69.81	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.03	gold quality
endometrium	UBERON:0001295	68.84	gold quality
tibial artery	UBERON:0007610	68.84	gold quality
transverse colon	UBERON:0001157	68.71	gold quality
intestine	UBERON:0000160	68.22	gold quality
heart left ventricle	UBERON:0002084	68.00	gold quality
cerebellar hemisphere	UBERON:0002245	67.55	gold quality
lung	UBERON:0002048	66.86	gold quality
Ammon’s horn	UBERON:0001954	66.80	gold quality
ascending aorta	UBERON:0001496	66.19	gold quality
colon	UBERON:0001155	65.79	gold quality
descending thoracic aorta	UBERON:0002345	65.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.13	gold quality
body of uterus	UBERON:0009853	64.24	gold quality
right adrenal gland cortex	UBERON:0035827	63.85	gold quality
endocervix	UBERON:0000458	63.72	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.54	gold quality
omental fat pad	UBERON:0010414	63.14	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.03	gold quality
skin of leg	UBERON:0001511	62.69	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.52	gold quality
putamen	UBERON:0001874	62.44	gold quality
minor salivary gland	UBERON:0001830	62.28	gold quality
right ovary	UBERON:0002118	62.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress. (PMID:37924725)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.