MIR3689B

Summary

MIR3689B (microRNA 3689b, HGNC:38924) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500906 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38924
Approved symbol	MIR3689B
Name	microRNA 3689b
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3689b
Ensembl gene	ENSG00000264163
Ensembl biotype	miRNA
Entrez	100500906
RNAcentral	URS000075A760 — miRNA, 148 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581772

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581772 — 1 exons

Exon	Start	End
ENSE00002728367	134850125	134850272

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 91.50.

Top tissues by expression

66 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.50	gold quality
monocyte	CL:0000576	76.93	gold quality
adrenal tissue	UBERON:0018303	76.52	gold quality
blood	UBERON:0000178	71.76	gold quality
placenta	UBERON:0001987	69.61	gold quality
stomach	UBERON:0000945	69.50	gold quality
endocervix	UBERON:0000458	69.05	gold quality
liver	UBERON:0002107	68.59	gold quality
right adrenal gland	UBERON:0001233	68.12	gold quality
left uterine tube	UBERON:0001303	67.74	gold quality
lung	UBERON:0002048	65.75	gold quality
smooth muscle tissue	UBERON:0001135	65.72	gold quality
gastrocnemius	UBERON:0001388	65.56	gold quality
left coronary artery	UBERON:0001626	65.25	gold quality
ascending aorta	UBERON:0001496	64.99	gold quality
calcaneal tendon	UBERON:0003701	64.45	gold quality
popliteal artery	UBERON:0002250	64.38	gold quality
heart	UBERON:0000948	64.37	gold quality
kidney	UBERON:0002113	64.19	gold quality
heart left ventricle	UBERON:0002084	64.18	gold quality
tibial artery	UBERON:0007610	64.13	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.98	gold quality
colon	UBERON:0001155	63.95	gold quality
intestine	UBERON:0000160	63.92	gold quality
thoracic aorta	UBERON:0001515	63.82	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.81	gold quality
omental fat pad	UBERON:0010414	63.77	gold quality
myometrium	UBERON:0001296	63.63	gold quality
body of pancreas	UBERON:0001150	63.42	gold quality
adipose tissue	UBERON:0001013	63.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.