MIR3689C

Summary

MIR3689C (microRNA 3689c, HGNC:41816) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616333 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41816
Approved symbol	MIR3689C
Name	microRNA 3689c
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3689c
Ensembl gene	ENSG00000264744
Ensembl biotype	miRNA
Entrez	100616333
RNAcentral	URS000075B954 — miRNA, 72 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581239

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581239 — 1 exons

Exon	Start	End
ENSE00002727344	134849298	134849369

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 77.33.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	77.33	gold quality
intestine	UBERON:0000160	70.96	gold quality
heart left ventricle	UBERON:0002084	70.72	gold quality
skin of leg	UBERON:0001511	69.81	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.74	gold quality
colon	UBERON:0001155	69.00	gold quality
tibial artery	UBERON:0007610	66.10	gold quality
transverse colon	UBERON:0001157	66.02	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.48	gold quality
body of stomach	UBERON:0001161	65.41	gold quality
stomach	UBERON:0000945	65.13	gold quality
omental fat pad	UBERON:0010414	64.69	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.39	gold quality
left ovary	UBERON:0002119	62.08	gold quality
prostate gland	UBERON:0002367	60.96	gold quality
cerebellar hemisphere	UBERON:0002245	60.50	gold quality
left lobe of thyroid gland	UBERON:0001120	60.08	gold quality
tibial nerve	UBERON:0001323	59.90	gold quality
body of uterus	UBERON:0009853	58.77	gold quality
upper lobe of left lung	UBERON:0008952	56.21	gold quality
testis	UBERON:0000473	48.66	gold quality
left testis	UBERON:0004533	48.37	gold quality
right testis	UBERON:0004534	45.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.