MIR3689D2

Summary

MIR3689D2 (microRNA 3689d-2, HGNC:41846) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616344 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41846
Approved symbol	MIR3689D2
Name	microRNA 3689d-2
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3689d-2
Ensembl gene	ENSG00000264136
Ensembl biotype	miRNA
Entrez	100616344
RNAcentral	URS000075D987 — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580187

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580187 — 1 exons

Exon	Start	End
ENSE00002698761	134850277	134850356

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 94.25.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.25	gold quality
lung	UBERON:0002048	77.58	gold quality
monocyte	CL:0000576	73.85	gold quality
stomach	UBERON:0000945	72.98	gold quality
left ovary	UBERON:0002119	69.67	gold quality
heart left ventricle	UBERON:0002084	68.71	gold quality
tibial nerve	UBERON:0001323	67.14	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.19	gold quality
colon	UBERON:0001155	64.49	gold quality
thoracic aorta	UBERON:0001515	64.08	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.62	gold quality
vagina	UBERON:0000996	62.56	gold quality
myometrium	UBERON:0001296	62.15	gold quality
skin of leg	UBERON:0001511	62.03	gold quality
transverse colon	UBERON:0001157	61.22	gold quality
right testis	UBERON:0004534	44.12	gold quality
left testis	UBERON:0004533	41.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.