MIR3689E

Summary

MIR3689E (microRNA 3689e, HGNC:41887) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616460 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41887
Approved symbol	MIR3689E
Name	microRNA 3689e
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3689e
Ensembl gene	ENSG00000266827
Ensembl biotype	miRNA
Entrez	100616460
RNAcentral	URS000075E296 — miRNA, 72 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582479

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582479 — 1 exons

Exon	Start	End
ENSE00002725287	134850570	134850641

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 68.11.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
intestine	UBERON:0000160	68.11	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.78	gold quality
tibial artery	UBERON:0007610	65.92	gold quality
skin of abdomen	UBERON:0001416	64.66	gold quality
upper lobe of left lung	UBERON:0008952	64.41	gold quality
left uterine tube	UBERON:0001303	63.07	gold quality
colon	UBERON:0001155	62.64	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	61.65	gold quality
tibial nerve	UBERON:0001323	61.47	gold quality
vagina	UBERON:0000996	60.01	gold quality
right frontal lobe	UBERON:0002810	59.72	gold quality
right testis	UBERON:0004534	47.56	gold quality
left testis	UBERON:0004533	44.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.