MIR369

Summary

MIR369 (microRNA 369, HGNC:31783) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 442914 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31783
Approved symbol	MIR369
Name	microRNA 369
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-369
Ensembl gene	ENSG00000199025
Ensembl biotype	miRNA
OMIM	611794
Entrez	442914
RNAcentral	URS000075D5A7 — miRNA, 70 nt, 19 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362155

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362155 — 1 exons

Exon	Start	End
ENSE00001436918	101065598	101065667

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 94.72.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	94.72	gold quality
skeletal muscle tissue	UBERON:0001134	89.01	gold quality
placenta	UBERON:0001987	81.88	gold quality
heart left ventricle	UBERON:0002084	81.57	gold quality
left ovary	UBERON:0002119	77.58	gold quality
adrenal gland	UBERON:0002369	76.57	gold quality
liver	UBERON:0002107	75.54	gold quality
right adrenal gland	UBERON:0001233	75.52	gold quality
ovary	UBERON:0000992	75.44	gold quality
muscle of leg	UBERON:0001383	74.82	gold quality
right adrenal gland cortex	UBERON:0035827	74.45	gold quality
stomach	UBERON:0000945	74.29	gold quality
left adrenal gland	UBERON:0001234	73.98	gold quality
heart	UBERON:0000948	73.32	gold quality
left adrenal gland cortex	UBERON:0035825	73.23	gold quality
body of pancreas	UBERON:0001150	72.67	gold quality
monocyte	CL:0000576	72.42	gold quality
endometrium	UBERON:0001295	71.86	gold quality
body of stomach	UBERON:0001161	71.69	gold quality
gastrocnemius	UBERON:0001388	71.58	gold quality
adipose tissue	UBERON:0001013	71.56	gold quality
vagina	UBERON:0000996	71.41	gold quality
omental fat pad	UBERON:0010414	71.35	gold quality
prefrontal cortex	UBERON:0000451	71.32	gold quality
lung	UBERON:0002048	71.09	gold quality
islet of Langerhans	UBERON:0000006	71.06	gold quality
blood	UBERON:0000178	69.93	gold quality
saliva-secreting gland	UBERON:0001044	69.74	gold quality
intestine	UBERON:0000160	68.53	gold quality
body of uterus	UBERON:0009853	68.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• miR-369-5p and miR-371 as antagonistic up-stream regulators of adipogenic differentiation and this might be indirectly mediated by epigenetic modifications. (PMID:21660946)
• The presence of at least one C allele is associated with a decreased expression of OLR1 mRNA in the absence of hsa-miR369-3p de-regulation (PMID:21709374)
• Low miR-369 expression is associated with chronic rejection in Bronchiolitis Obliterans Syndrome patients following lung transplantation. (PMID:25649290)
• A unique role of the embryonic miR-369-HNRNPA2B1 axis in controlling metabolic enzyme function. (PMID:26176628)
• This study demonstrated that overexpression of miR-369-3p in glioblastoma cells inhibited their proliferation and migration in vitro. Mice implanted with glioblastoma cells overexpressing miR369-3p. (PMID:27573219)
• aberrant expression of miR-369-3p might play a crucial role in the development HSCR by regulating SOX4 expression, which may infer that it is an effective diagnostic target in the pathogenesis of HSCR, but investigation is still needed to explore the underlying mechanism. (PMID:28412032)
• LncRNA OIP5-AS1 suppressed cell viability, promoted radio-induced apoptosis, and enhanced the radiosensitivity of CRC cells by regulating DYRK1A expression through miR-369-3p. (PMID:29773344)
• downregulation of miR-369-3p and consequent upregulation of its target TSPAN13 appear to be involved in pathophysiology of papillary thyroid cancer (PMID:30114378)
• These findings provide convincing evidence that both the 5p and 3p arms of miRNA co-expressed in gastric cancer (GC) and DNA methylation-induced miR-369 signaling contribute to GC progression. (PMID:31162777)
• LncRNA SOX2 overlapping transcript (SOX2-OT) expression was conspicuously elevated in prostate cancer (PC) tissues and cells. Silenced SOX2-OT could repress PC cell proliferation and migration. SOX2-OT bound with miR-369-3p and negatively correlated with miR-369-3p in PC. Cofilin 2 (CFL2) was found to be a downstream target gene of miR-369-3p. (PMID:31623830)
• Fibroblastderived exosomal microRNA369 potentiates migration and invasion of lung squamous cell carcinoma cells via NF1mediated MAPK signaling pathway. (PMID:32467987)
• MiR-369-3p inhibits tumorigenesis of hepatocellular carcinoma by binding to PAX6. (PMID:32608213)
• Knockdown of long noncoding RNA DLEU2 suppresses idiopathic pulmonary fibrosis by regulating the microRNA3693p/TRIM2 axis. (PMID:33760118)
• miR-369-3p serves as prognostic factor and regulates cancer progression of hepatocellular carcinoma. (PMID:33792408)
• [Molecular mechanism of miR-369-3p regulating hepatocellular carcinoma cell proliferation and apoptosis by targeting ACTN4]. (PMID:34794217)
• MiR-369-5p inhibits the proliferation and migration of hepatocellular carcinoma cells by down-regulating HOXA13 expression. (PMID:34979376)
• A Novel Mechanism of Immunoproteasome Regulation via miR-369-3p in Intestinal Inflammatory Response. (PMID:36430249)
• miR-369-3p Modulates Intestinal Inflammatory Response via BRCC3/NLRP3 Inflammasome Axis. (PMID:37681916)
• Anti-Inflammatory Effects of miR-369-3p via PDE4B in Intestinal Inflammatory Response. (PMID:39126032)

Cross-species orthologs

0 orthologs

Paralogs (16): MIR494 (ENSG00000194717), MIR377 (ENSG00000199015), MIR381 (ENSG00000199020), MIR323A (ENSG00000199069), MIR410 (ENSG00000199092), MIR409 (ENSG00000199107), MIR539 (ENSG00000202560), MIR487A (ENSG00000207742), MIR487B (ENSG00000207754), MIR656 (ENSG00000207959), MIR496 (ENSG00000207961), MIR154 (ENSG00000207978), MIR323B (ENSG00000208004), MIR1185-1 (ENSG00000221525), MIR1185-2 (ENSG00000221614), MIR382 (ENSG00000283170)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.