MIR3691

Summary

MIR3691 (microRNA 3691, HGNC:38909) is a microRNA gene on chromosome 6p25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500900 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38909
Approved symbol	MIR3691
Name	microRNA 3691
Location	6p25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3691
Ensembl gene	ENSG00000265083
Ensembl biotype	miRNA
Entrez	100500900
RNAcentral	URS000075D0E7 — miRNA, 90 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578066

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578066 — 1 exons

Exon	Start	End
ENSE00002725093	5148233	5148322

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 96.30.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.30	gold quality
blood	UBERON:0000178	80.89	gold quality
kidney	UBERON:0002113	78.73	gold quality
lymph node	UBERON:0000029	75.00	gold quality
monocyte	CL:0000576	74.55	gold quality
adult mammalian kidney	UBERON:0000082	74.47	gold quality
adrenal tissue	UBERON:0018303	73.39	gold quality
liver	UBERON:0002107	73.25	gold quality
stomach	UBERON:0000945	71.77	gold quality
left adrenal gland	UBERON:0001234	70.53	gold quality
gastrocnemius	UBERON:0001388	70.43	gold quality
heart	UBERON:0000948	69.91	gold quality
body of stomach	UBERON:0001161	69.10	gold quality
heart left ventricle	UBERON:0002084	68.99	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.74	gold quality
endometrium	UBERON:0001295	68.58	gold quality
body of pancreas	UBERON:0001150	68.38	gold quality
tibial artery	UBERON:0007610	68.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.08	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.01	gold quality
left adrenal gland cortex	UBERON:0035825	67.81	gold quality
lung	UBERON:0002048	67.48	gold quality
ascending aorta	UBERON:0001496	67.36	gold quality
transverse colon	UBERON:0001157	66.88	gold quality
right adrenal gland	UBERON:0001233	66.81	gold quality
Ammon’s horn	UBERON:0001954	66.74	gold quality
putamen	UBERON:0001874	66.63	gold quality
right ovary	UBERON:0002118	66.42	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.20	gold quality
multicellular organism	UBERON:0000468	66.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-3691-5p is upregulated in docosahexaenoic acid-treated vascular endothelial cell and targets serpin family E member 1. (PMID:31674071)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.