MIR370

Summary

MIR370 (microRNA 370, HGNC:31784) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 442915 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31784
Approved symbol	MIR370
Name	microRNA 370
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-370
Ensembl gene	ENSG00000199005
Ensembl biotype	miRNA
OMIM	612553
Entrez	442915
RNAcentral	URS000075B235 — miRNA, 75 nt, 16 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362135

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362135 — 1 exons

Exon	Start	End
ENSE00001436898	100911139	100911213

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 99.06.

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.06	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.30	gold quality
placenta	UBERON:0001987	85.74	gold quality
kidney	UBERON:0002113	81.47	gold quality
lung	UBERON:0002048	77.88	gold quality
prefrontal cortex	UBERON:0000451	77.45	gold quality
adrenal gland	UBERON:0002369	76.02	gold quality
blood	UBERON:0000178	75.95	gold quality
muscle of leg	UBERON:0001383	75.13	gold quality
stomach	UBERON:0000945	75.02	gold quality
adult mammalian kidney	UBERON:0000082	74.49	gold quality
left adrenal gland cortex	UBERON:0035825	74.28	gold quality
gastrocnemius	UBERON:0001388	74.24	gold quality
monocyte	CL:0000576	73.89	gold quality
left adrenal gland	UBERON:0001234	73.85	gold quality
calcaneal tendon	UBERON:0003701	73.02	gold quality
islet of Langerhans	UBERON:0000006	72.59	gold quality
endometrium	UBERON:0001295	72.34	gold quality
left ovary	UBERON:0002119	72.13	gold quality
heart	UBERON:0000948	72.01	gold quality
ovary	UBERON:0000992	71.75	gold quality
heart left ventricle	UBERON:0002084	71.41	gold quality
pituitary gland	UBERON:0000007	71.09	gold quality
right adrenal gland	UBERON:0001233	71.05	gold quality
adenohypophysis	UBERON:0002196	70.85	gold quality
liver	UBERON:0002107	70.66	gold quality
right ovary	UBERON:0002118	70.55	gold quality
body of pancreas	UBERON:0001150	70.50	gold quality
right adrenal gland cortex	UBERON:0035827	70.09	gold quality
gall bladder	UBERON:0002110	69.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• IL-6 may contribute to tumor growth by modulation of expression of selected miRNAs, such as miR-370. (PMID:17621267)
• TGFbeta1-mediated repression in cell migration was reverted by exogenous miR-370 expression. A reverse correlation between miR-370 and TGFbeta-RII expression was noted in GC tissues (PMID:21666718)
• Plasma levels of miR-122 and miR-370 were significantly increased in hyperlipidemia patients and were were positively correlated with elevated serum lipids. (PMID:22587332)
• miR-370 may function as a tumor suppressor by targeting FoxM1, and the epigenetic silence of miR-370 thus leads to derepression of FoxM1 expression and consequently contributes to AML development and progression. (PMID:22900969)
• MiR-370 can downregulate expression of FOXO1 by directly targeting the FOXO1 upstream untranslated region. (PMID:23029264)
• Our results suggest a leukemogenic role of miR-370 through NF1 downregulation in AML cells (PMID:23077663)
• Data indicate that the paternal allele of miR-370 is normally silenced through genomic imprinting and that the overexpression of IL-6 in CCA effectively suppresses the expression of miR-370 from the maternal allele. (PMID:23110045)
• Stat3 inhibits WTX expression through up-regulation of micro RNA-370 in Wilms tumor. (PMID:23333300)
• Results show that the miR-370-FoxM1 pathway is involved in the progress of gastritis toward gastric cancer induced by H. pylori infection. (PMID:23576572)
• Overexpression of miR-370 in gastric cancer cells promoted the cell proliferation. (PMID:23721824)
• data demonstrate the involvement of a novel regulatory circuit consisting of miR-370, LIN28A, RelA/p65 and IL-6 in HCC progression. (PMID:23728999)
• miR-370 may function as a tumor suppressor in laryngeal squamous cell carcinoma through downregulation of FoxM1, suggesting that miR-370 could serve as a novel potential maker for LSCC therapy. (PMID:24055400)
• High miR-370 expression is associated with aggressive lung adenocarcinoma. (PMID:24833665)
• Endoglin (ENG) is directly and negatively regulated by miR-370 in endometrioid ovarian cancer. (PMID:25063739)
• These data demonstrated the negative regulation between miR-146a and SOS1 and between miR-370 and GADD45beta and that these regulations are influenced by enterovirus 71 to induce apoptosis. (PMID:25469565)
• Results show that miR-370 expression is downregulated in non-small cell lung cancer (NSCLC), its overexpression inhibits tumor formation in vivo and targets TRAF4 suggesting it as an important player in NSCLC pathogenesis through TRAF4 regulation. (PMID:25976502)
• miRNA 370 is a potential marker for the prognosis and follow up of patients with type 2 diabetes at risk to develop coronary artery disease. (PMID:25978320)
• The results show that miR-370 and miR-373 contribute to the pathogenesis of osteoarthritis (OA) and act as negative regulators of SHMT-2 and MECP-2, respectively. (PMID:26103880)
• Taken together, these results revealed that the upregulation of miR-370 might facilitate the repair of amputated fingers by regulating angiogenesis through targeting FOXO1. (PMID:26316586)
• miR-370 inhibited cell growth and metastasis in osteosarcoma cells by down-regulation of FOXM1. (PMID:26617733)
• MiR-370 expression may be markedly and consistently decreased in pediatric acute myeloid leukemia patients and in turn contributes to aggressive progression of this malignancy (PMID:26823789)
• these data indicate that miRs-134 and -370 are potential tumour suppressor miRNAs and could play a fundamental role in suppressing colorectal cancer tumorigenesis through their ability to co-ordinately regulate EGFR signalling cascade by independently targeting EGFR and PIK3CA. (PMID:27095166)
• Study found that miR-370-3p had low expression levels in glioma tissues and that it served as a tumor suppressor by inhibiting glioma cell growth. Cell growth was inhibited by directly targeting beta-catenin and negatively regulating the expression of two genes downstream of the Wnt/beta-catenin pathway, cyclin D1 and c-myc. (PMID:27138069)
• In this study, a luciferase assay was used to investigate whether miR-370 modulated docking protein 3 (DOK3) gene expression when rs2279398G>A was included in the DOK3 3’-UTR region. (PMID:27354594)
• Knockdown of SLD5 using small interfering RNA resulted in reduction of cell growth both in vitro and an in vivo xenograft model. Moreover, we found that high levels of SLD5 in bladder cancer cells result from downregulation of microRNA (miR)-370 that otherwise suppresses its expression. (PMID:27499248)
• Low miR370 expression is associated with gastric cancer. (PMID:27499479)
• Low miR370 expression is associated with glioblastoma multiforme resistance to temozolomide. (PMID:27595933)
• Altogether, these results demonstrated that miR-370 suppressed hepatitis B virus gene expression and replication through repressing NFIA expression, which stimulates hepatitis B virus replication via direct regulation on hepatitis B virus Enhancer I activities. (PMID:27664977)
• EGFR protein expression is regulated by miR-370 and the miR-370-EGFR pathway is involved in the process of cell growth and migration in gastric cancer. (PMID:28534999)
• Data suggest that expression of CYP2D6 in hepatocytes is repressed by MIRN370 (hsa-miR-370-3p); MIRN370 represses expression of CYP2D6 even under the influence of CYP2D6 inducer (the glucocorticoid dexamethasone); the mechanism appears to involve the facilitation of CYP2D6 mRNA degradation. (CYP2D6 = cytochrome P450 family 2 subfamily D member 6; MIRN370 = microRNA 370) (PMID:28552654)
• Overexpression of these two microRNAs in A549 induced cell-cycle arrest and cell senescence, delayed cell proliferation and colony formation, and inhibited migration and invasion. In conclusion, microRNA-mediated RNAa depends on the cell context, and miR-1236 and miR-370 can inhibit non-small-cell lung carcinoma cell growth by upregulating p21 expression in vitro (PMID:28631573)
• Low level of miR-370 correlates with poor prognosis in patients with hepatocellular carcinoma (PMID:28925487)
• results have identified an miR-370-3p/Wnt7a axis that controls UBC invasion through canonical Wnt/beta-catenin signaling, which may offer prognostic and therapeutic opportunities (PMID:29549123)
• Downregulation of miR-370 in esophageal squamous cell carcinoma is associated with cancer progression and promotes cancer cell proliferation via upregulating PIN1, which might be a potential therapeutic target and adverse prognostic factor in the clinic. (PMID:29605603)
• Low expression of MIR370 is associated with vascular inflammation and oxidative stress. (PMID:29663491)
• Our findings suggest that miR-370 functions as an HCC tumor suppressor and regulator of IFN-alpha sensitivity and that miR-370 might be a useful prognostic marker for HCC patients. (PMID:29758929)
• results found that P-selectin-induced elevations of p-p38 and p-PI3K levels were significantly inhibited by hsa-miR-370, indicating that repressed sLe(x) level is able to reduce the P-selectin binding and therefore eliminating the P-selectin-induced activation of p38 and PI3K signaling. (PMID:29922946)
• Results suggest for the first time a role for miR-370 and miR-543 and its target DNAJB1 in the pathogenesis of spinocerebellar ataxia type 3 (SCA3). In human neuronal cultures derived from SCA3 patient-specific induced pluripotent stem cell (iPSC) lines, miR-370 and miR-543 levels are upregulated, while DNAJB1 expression is concurrently reduced. (PMID:30086154)
• CircNEK6 promoted the progression of thyroid cancer through up-regulating FZD8 and activating Wnt signaling pathway by targeting miR-370-3p. (PMID:30207869)
• MicroRNA-370 inhibits the proliferation, invasion and EMT of gastric cancer cells by directly targeting PAQR4. (PMID:30322804)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir370	ENSMUSG00000065433
rattus_norvegicus	Mir370	ENSRNOG00000035615

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.