MIR3713

Summary

MIR3713 (microRNA 3713, HGNC:38926) is a microRNA gene on chromosome 15q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500855 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38926
Approved symbol	MIR3713
Name	microRNA 3713
Location	15q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3713
Ensembl gene	ENSG00000266449
Ensembl biotype	miRNA
Entrez	100500855
RNAcentral	URS000075CF19 — ncRNA, 45 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581359

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581359 — 1 exons

Exon	Start	End
ENSE00002714458	76586647	76586691

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 81.41.

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	81.41	gold quality
kidney	UBERON:0002113	80.95	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	74.86	gold quality
gastrocnemius	UBERON:0001388	74.76	gold quality
adrenal tissue	UBERON:0018303	74.32	gold quality
intestine	UBERON:0000160	74.21	gold quality
monocyte	CL:0000576	73.99	gold quality
body of stomach	UBERON:0001161	73.66	gold quality
liver	UBERON:0002107	73.23	gold quality
endometrium	UBERON:0001295	71.35	gold quality
anterior cingulate cortex	UBERON:0009835	71.19	gold quality
right atrium auricular region	UBERON:0006631	71.04	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.96	gold quality
stomach	UBERON:0000945	70.66	gold quality
body of pancreas	UBERON:0001150	70.33	gold quality
tibial artery	UBERON:0007610	70.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.85	gold quality
prostate gland	UBERON:0002367	69.52	gold quality
tibial nerve	UBERON:0001323	69.43	gold quality
ascending aorta	UBERON:0001496	69.41	gold quality
skin of leg	UBERON:0001511	69.21	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.39	gold quality
esophagus mucosa	UBERON:0002469	68.33	gold quality
caudate nucleus	UBERON:0001873	68.07	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.04	gold quality
colon	UBERON:0001155	67.69	gold quality
left ovary	UBERON:0002119	67.31	gold quality
spleen	UBERON:0002106	66.94	gold quality
putamen	UBERON:0001874	66.80	gold quality
omental fat pad	UBERON:0010414	65.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The effects of miR-3713 on Transitional cell carcinoma (TCC) cell growth appeared to result from its modification of MMP9 levels, in which miR-3713 was found to bind to the 3’-UTR of MMP9 mRNA to inhibit its protein translation in TCC cells (PMID:27577949)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.