MIR371B

Summary

MIR371B (microRNA 371b, HGNC:41863) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616185 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41863
Approved symbol	MIR371B
Name	microRNA 371b
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-371b
Ensembl gene	ENSG00000284568
Ensembl biotype	miRNA
Entrez	100616185
RNAcentral	URS000075DDDA — ncRNA, 66 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000638082

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000638082 — 1 exons

Exon	Start	End
ENSE00003794757	53787677	53787742

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 79.43.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	79.43	gold quality
blood	UBERON:0000178	67.49	gold quality
subcutaneous adipose tissue	UBERON:0002190	59.81	gold quality
spleen	UBERON:0002106	52.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• mir-371b-5p expression was higher in patients with SLE compared to controls, in patients with SLE compared to patients with rheumatoid arthritis, and in patients with active SLE compared to inactive SLE. (PMID:30304699)
• The Relevance of SNPs at 3’UTR Region of CASP7 and miR-371b-5p Associated Diseases: A Computational Analysis. (PMID:32951155)
• miR-371b-5p promotes cell proliferation, migration and invasion in non-small cell lung cancer via SCAI. (PMID:33103723)
• Serum miR371 in testicular germ cell cancer before and after orchiectomy, assessed by digital-droplet PCR in a prospective study. (PMID:34341387)
• Reduced miR-371b-5p expression drives tumor progression via CSDE1/RAC1 regulation in triple-negative breast cancer. (PMID:35490208)
• The beta-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance. (PMID:37106379)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.