MIR373

Summary

MIR373 (microRNA 373, HGNC:31787) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 442918 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31787
Approved symbol	MIR373
Name	microRNA 373
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-373
Ensembl gene	ENSG00000199143
Ensembl biotype	miRNA
OMIM	611954
Entrez	442918
RNAcentral	URS000075BF4B — miRNA, 69 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362273

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362273 — 1 exons

Exon	Start	End
ENSE00001437036	53788705	53788773

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 83.11.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	83.11	gold quality
leukocyte	CL:0000738	82.17	gold quality
blood	UBERON:0000178	81.86	gold quality
bone marrow	UBERON:0002371	75.30	gold quality
granulocyte	CL:0000094	75.21	gold quality
gastrocnemius	UBERON:0001388	74.84	gold quality
left adrenal gland cortex	UBERON:0035825	74.20	gold quality
heart left ventricle	UBERON:0002084	73.09	gold quality
omental fat pad	UBERON:0010414	68.76	gold quality
tibial artery	UBERON:0007610	68.64	gold quality
heart	UBERON:0000948	68.30	gold quality
prostate gland	UBERON:0002367	68.03	gold quality
endometrium	UBERON:0001295	67.97	gold quality
right atrium auricular region	UBERON:0006631	66.03	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.87	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.51	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.82	gold quality
skin of abdomen	UBERON:0001416	64.32	gold quality
right frontal lobe	UBERON:0002810	63.68	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.63	gold quality
lung	UBERON:0002048	63.56	gold quality
skin of leg	UBERON:0001511	63.39	gold quality
spleen	UBERON:0002106	63.07	gold quality
vagina	UBERON:0000996	62.58	gold quality
thyroid gland	UBERON:0002046	62.58	gold quality
minor salivary gland	UBERON:0001830	62.21	gold quality
pituitary gland	UBERON:0000007	61.83	gold quality
upper lobe of left lung	UBERON:0008952	61.09	gold quality
tibial nerve	UBERON:0001323	54.31	gold quality
left testis	UBERON:0004533	44.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• miRNA-372 and miRNA-373 have roles as oncogenes in testicular germ cell tumors (PMID:17695719)
• Transfection of miR-373 and its precursor hairpin RNA (pre-miR-373) into PC-3 cells readily induced E-cadherin ans CSDC2 gene expression. (PMID:18227514)
• Data show that LATS2 protein expression is mediated by miR-373 at the post-transcriptional level and inversely correlates with miR-373 amounts in esophageal cancer cell lines. (PMID:19501585)
• In hilar cholangiocarcinoma, down-expression of miR-373 leads to increase of MBD2, which in turn suppresses the methylation-mediated gene such as RASSF1A. (PMID:21086164)
• miR-373 is a methylation-mediated gene and the implication of MBD2 in methylation-mediated suppression of miR-373 plays an important role in tumourigenesis and development in hilar cholangiocarcinoma. (PMID:21165562)
• miR-373 can regulate cell cycle progression by targeting PPP6C transcripts and promotes the growth activity of HCC cells in vitro. The downregulation of PPP6C by miR-373 may explain why the expression of miR-373 can promote HCC cell proliferation. (PMID:21481188)
• study revealed that miRNA (miRs-372/373) can promote HBV expression through a pathway involving the transcription factor (PMID:21608007)
• Results sugggest that histone deacetylation of E-cadherin (CDH1) and downregulation of miR-373, together with the hypermethylation of CDH1 by hepatitis B virus-encoded X antigen, HBx, may be important for the understanding of HBV-related carcinogenesis. (PMID:21706058)
• miR-520/373 family has a tumor-suppressive role in ER(-) breast cancer by acting as a link between the NF-kappaB and TGF-beta pathways and may thus contribute to the interplay of tumor progression, metastasis and inflammation. (PMID:22158050)
• pri-miRNAs-371-373_ht2 [C-A-C] haplotype were more protective to hepatocellular carcinoma (HCC) occurrence in patients with HBV infection; the polymorphism of pri-miRNAs-371-373 was not associated with spontaneous HBV clearance (PMID:22848681)
• MiR-373 behaves as a direct transcriptional target and negative regulator of MBD2 activity through a feedback loop of CpG island methylation in hilar cholangiocarcinoma (PMID:22876037)
• study observed that circulating miR-10b and miR-373 levels could distinguish breast cancer patients with lymph node metastasis from non-metastatic patients (PMID:23238818)
• Mir-373 affects human lung cancer cells’ growth and its E-cadherin expression. (PMID:23461063)
• ZIP4 activates the zinc-dependent transcription factor CREB and requires this transcription factor to increase miR-373 expression through the regulation of its promoter. (PMID:23857777)
• Targeted serum miRNA (TSmiR) test for diagnosis and follow-up of (testicular) germ cell cancer patients: a proof of principle. (PMID:24012110)
• onco-miR-372-373 has a role in testicular germ cell tumours; its imprinted antisense transcript anti-miR-371-3 has a tumour suppressive role (PMID:24201333)
• TGFbeta signaling regulates miR373, which promotes mesendoderm differentiation in human embryonic stem cells (PMID:24709321)
• MiR-373 is down-regulated in pancreatic cancer, and its reexpression represses the invasiveness of pancreatic cancer cells. (PMID:24748127)
• Human miR-373 is silenced by histone modification in lung cancer cells and is a negative regulator of the mesenchymal phenotype through downstream IRAK2 and LAMP1 target genes. (PMID:25063738)
• High Serum levels of miR-373 is associated with pathological response to chemotherapy in HER2-positive breast cancer. (PMID:25086636)
• Data indicate that serum levels of exosomal miR-373 are linked to triple negative and more aggressive breast carcinomas. (PMID:25333260)
• these results demonstrate that miR-373 suppresses epithelial ovarian cancer invasion and metastasis by directly targeting Rab22a gene (PMID:25460499)
• we found that miR-373 and -520c down-regulated the activities of MMP2 in various cancer cell lines but simultaneously up-regulated the expression of MMP9 gene only in HT1080 cells (PMID:25545756)
• HCV infection upregulates miR-373 expression and impairs the JAK/STAT signaling pathway. (PMID:25589644)
• miR-373 increases proliferation by directly targeting YOD1 in cervical cancer. (PMID:25747718)
• Low MIR373 expression is associated with cell cycle arrest in unrestricted somatic stem cells. (PMID:25941115)
• analysis of the functions of miR-373 and its implication in cancers [review] (PMID:25990556)
• The results show that miR-370 and miR-373 contribute to the pathogenesis of osteoarthritis (OA) and act as negative regulators of SHMT-2 and MECP-2, respectively. (PMID:26103880)
• TXNIP was regulated by miR-373. miR-373 could promote the invasion and migration of breast cancer. (PMID:26122224)
• MiR-373-3p participated in the invasion and metastasis of lung adenocarcinoma cells, partly by upregulation of MMP-9 and MMP-14. (PMID:26182868)
• Activation of the miR-373-TXNIP-HIF1alpha-TWIST signaling axis is correlated with a worse outcome in patients with breast cancer. (PMID:26196741)
• Data suggest that microRNAs miR-10b, 21, 200c, 373 and 520c may control both metastasis and stemness potential. (PMID:26208390)
• Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer. (PMID:26258411)
• A serum/CSF miRNA panel (miR-371a-3p, miR-372-3p, miR-373-3p and miR-367-3p) was sensitive and specific for diagnosing pediatric extracranial malignant GCT as well as detecting relapse, and distinguishing GCT vs. non-GCT intracranial neoplasms. (PMID:26671749)
• CD44 and TGFBR2 are the functional targets of miR-373, which are responsible for the tumor suppressive functions of miR-373 (PMID:26858153)
• Down-regulation of TRPS1 by miR-373, acting as a transcriptional activator, promotes epithelial-mesenchymal transition (EMT) and metastasis by repressing FOXA1 transcription, expanding upon its previously reported role as a transcription repressor. (PMID:26969828)
• First evidence that miR-205 and miR-373 may differentially contribute to the aggressive phenotype of Mucinous adenocarcinoma in colorectal cancer. (PMID:27271572)
• Our data suggest an important role of beta2-AR/STAT3/miR-373 signaling on the transformation of gastric cancer cells. (PMID:27512943)
• The serum concentrations of cell-free microRNAs miR-373, miR-200a, miR-200b and miR-200c were significantly higher in epithelial ovarian cancer (EOC) patients. (PMID:27753009)
• our findings reveal a new regulatory mechanism for miR-373-3p and suggest that miR-373-3p might be a potential target in tongue squamous cell carcinoma therapy (PMID:28337453)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.