MIR374A

Summary

MIR374A (microRNA 374a, HGNC:31788) is a microRNA gene on chromosome Xq13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 442919 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31788
Approved symbol	MIR374A
Name	microRNA 374a
Location	Xq13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-374, hsa-mir-374a
Ensembl gene	ENSG00000199168
Ensembl biotype	miRNA
Entrez	442919
RNAcentral	URS000075BDBF — miRNA, 72 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362298

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362298 — 1 exons

Exon	Start	End
ENSE00001437061	74287286	74287357

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 85.14.

Top tissues by expression

41 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	85.14	gold quality
blood	UBERON:0000178	78.01	gold quality
adrenal tissue	UBERON:0018303	76.64	gold quality
monocyte	CL:0000576	75.36	gold quality
adult mammalian kidney	UBERON:0000082	72.52	gold quality
gastrocnemius	UBERON:0001388	71.31	gold quality
liver	UBERON:0002107	70.86	gold quality
stomach	UBERON:0000945	70.79	gold quality
intestine	UBERON:0000160	69.51	gold quality
left adrenal gland cortex	UBERON:0035825	68.27	gold quality
endometrium	UBERON:0001295	67.23	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.23	gold quality
body of stomach	UBERON:0001161	67.20	gold quality
fundus of stomach	UBERON:0001160	66.58	gold quality
spleen	UBERON:0002106	66.58	gold quality
esophagus	UBERON:0001043	66.39	gold quality
ascending aorta	UBERON:0001496	65.70	gold quality
body of pancreas	UBERON:0001150	65.46	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.93	gold quality
skin of leg	UBERON:0001511	64.33	gold quality
skin of abdomen	UBERON:0001416	64.08	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.98	gold quality
right ovary	UBERON:0002118	63.87	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.64	gold quality
transverse colon	UBERON:0001157	63.36	gold quality
esophagus mucosa	UBERON:0002469	63.15	gold quality
ovary	UBERON:0000992	63.02	gold quality
left ovary	UBERON:0002119	62.19	gold quality
hypothalamus	UBERON:0001898	61.67	gold quality
cerebellar hemisphere	UBERON:0002245	61.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• findings show that low expression of miR-374a in early-stage nonsmall cell lung cancer is associated with poor patient survival (PMID:21748820)
• Wnt/beta-catenin signaling is hyperactivated in metastatic breast cancer cells that express microRNA 374a (PMID:23321667)
• Up-regulation of miR-374A is associated with triple negative breast cancer. (PMID:23405235)
• Low miR-374a expression is associated with breast cancer. (PMID:23679262)
• increased PBEF/NAMPT expression induced by bioactive agonists involves epigenetic regulation with hsa-miR-374a and hsa-miR-568 (PMID:24053186)
• Report that miR-374a and miR-548b modulation by Axl regulates tumorigenicity and gefitinib resistance in lung cancer. (PMID:24832599)
• The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression. (PMID:25299640)
• these findings suggest that miR-374a functions as a candidate oncogene in GC by directly targeting SRCIN1 (PMID:25554419)
• We have shown a significant step-wise downregulation of hsa-miR-374a expression in cord blood of infants with perinatal asphyxia and subsequent HIE (PMID:26001314)
• the deregulation of miR-374a and miR-130a may be involved in the development and regulation of cisplatin resistance in ovarian cancer cells. (PMID:26043084)
• Axin2, a tumor suppressor, exhibited a marked inhibitory effect on Eca109 cell growth. The results identified a new role of miR-374a in esophageal cancer involving Axin2 suppression (PMID:26252180)
• Data suggest that patients with IgA nephropathy exhibit higher microRNA-374b in B cells compared to controls; microRNA-374b appears to target PTEN (phosphatase and tensin homolog) and Cosmc (C1GALT1 specific chaperone 1) proteins. (PMID:26545495)
• miR-374a functions as an oncogene in osteosarcoma, and the miR-374a/Axin2 axis might represent a potential therapeutic target for OS intervention. (PMID:26617789)
• these findings suggest that lnc-FTX may act as a tumor suppressor in hepatocellular carcinoma (HCC) through physically binding miR-374a and MCM2. It may also be one of the reasons for HCC gender disparity and may potentially contribute to HCC treatment. (PMID:27065331)
• MiR-374a inactivates the PI3K/AKT axis by inhibiting CCND1, suppressing of colon cancer progression. (PMID:27191497)
• MiR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. (PMID:27207663)
• miRNA miR-374 has the potential to be a new radiosensitizer for carbon ion beam radiotherapy and a new biomarker to determine the optimal treatment for cancer. (PMID:27665739)
• data suggest miR-374a is a negative regulator of Fas death receptor which is able to enhance the cell survival and protect retinal pigment epithelial cells against oxidative conditions. (PMID:28543858)
• we suggest that the dysfunction of the XIST/miR-374a/LARP1 axis contributes to non-small cell lung cancer (NSCLC)and may serve as a promising therapeutic strategy for treatment. (PMID:29039571)
• MiR-374a could help to elevate the diagnostic value and prognostic prediction of S100B protein, miR-210 and neuron-specific enolase for Hypoxic-Ischemic Encephalopathy. (PMID:29568675)
• Low miR374a expression is associated with inflammatory process in obesity. (PMID:29769661)
• The relative expression of miR-374-5p was significantly upregulated in relapsed lung adenocarcinoma samples using FFPE tissue, which showed possible clinical utility as biomarkers predicting recurrence after curative surgery. (PMID:29923982)
• MiR-374a specifically targets WNT5A, a noncanonical Wnt ligand that activates canonical Wnt signaling in the presence of specific receptors in bladder cancer cells, abrogates the invasiveness and metastasis potential, and increases apoptosis after cisplatin treatment. (PMID:30032142)
• MiR-374a Activates Wnt/beta-Catenin Signaling to Promote Osteosarcoma Cell Migration by Targeting WIF-1. (PMID:30523602)
• In this review, we mainly focus on the role of miR-374 family members in multiple physiological and pathological processes. (PMID:30772950)
• MicroRNA-374b promotes the development of LC by down regulating PTEN expression through activating PI3K/Akt pathway. (PMID:30779080)
• we demonstrated the effect of miR-374a inhibitor/FOXO1 axis on sensitizing glioma cells to VP-16-based chemotherapy (PMID:30841958)
• our data revealed that lncRNA MAGI2-AS3 is involved in breast cancer cell progression by regulating the miR-374a-PTEN axis. (PMID:30883342)
• this study revealed that miR-374a promoted cell proliferation, migration and EMT via targeting SRCIN1 in pancreatic cancer (PMID:30890278)
• Combined gene expression profiling of miRNA-microarray and human transcriptome dataset analysis revealed that miR-374a-5p is specifically upregulated in TNBC patients. miR-374a-5p was also found to directly target arrestin beta 1 (ARRB1) that is specifically downregulated in TNBC patients in several human genomic datasets. (PMID:31004703)
• LINC00473/miR-374a-5p regulates esophageal squamous cell carcinoma via targeting SPIN1 to weaken the effect of radiotherapy. (PMID:31017716)
• a novel mechanism of miR-374a/Myc axis modulating iron overload-induced production of reactive oxygen species and the activation of hepatic stellate cells via TGF-beta1 and IL-6, is reported. (PMID:31171361)
• MicroRNA-374b inhibits migration and invasion of glioma cells by targeting EGFR. (PMID:31173297)
• Propofol inhibits proliferation and cisplatin resistance in ovarian cancer cells through regulating the microRNA374a/forkhead box O1 signaling axis. (PMID:32016462)
• Up-regulated miR-374a-3p relieves lipopolysaccharides induced injury in CHON-001 cells via regulating Wingless-type MMTV integration site family member 5B. (PMID:32092330)
• Long non-coding RNA MALAT1 regulates proliferation, apoptosis, migration and invasion via miR-374b-5p/SRSF7 axis in non-small cell lung cancer. (PMID:32141554)
• LINC-PINT suppresses tumour cell proliferation, migration and invasion through targeting miR-374a-5p in ovarian cancer. (PMID:32638404)
• High expression of miR-374a-5p inhibits the proliferation and promotes differentiation of Rencell VM cells by targeting Hes1. (PMID:32949667)
• LINC02288 promotes chondrocyte apoptosis and inflammation through miR-374a-3p targeting RTN3. (PMID:33491257)
• Dysregulation of miR-374a is involved in the progression of diabetic retinopathy and regulates the proliferation and migration of retinal microvascular endothelial cells. (PMID:33941051)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir374c	ENSMUSG00000106465

Paralogs (1): MIR374B (ENSG00000212027)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.