MIR374C

Summary

MIR374C (microRNA 374c, HGNC:38907) is a microRNA gene on chromosome Xq13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500807 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38907
Approved symbol	MIR374C
Name	microRNA 374c
Location	Xq13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-374c
Ensembl gene	ENSG00000283534
Ensembl biotype	miRNA
Entrez	100500807
RNAcentral	URS000075D5D3 — miRNA, 70 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637743

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637743 — 1 exons

Exon	Start	End
ENSE00003792128	74218549	74218618

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 95.99.

Top tissues by expression

150 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar vermis	UBERON:0004720	95.99	gold quality
cerebellar hemisphere	UBERON:0002245	87.69	gold quality
pericardium	UBERON:0002407	86.57	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	85.58	gold quality
tendon of biceps brachii	UBERON:0008188	84.38	silver quality
tendon	UBERON:0000043	81.45	gold quality
corpus epididymis	UBERON:0004359	77.39	gold quality
germinal epithelium of ovary	UBERON:0001304	77.31	silver quality
caput epididymis	UBERON:0004358	75.12	gold quality
cauda epididymis	UBERON:0004360	73.22	gold quality
pons	UBERON:0000988	72.79	gold quality
tibia	UBERON:0000979	72.62	gold quality
cerebellum	UBERON:0002037	72.43	silver quality
middle temporal gyrus	UBERON:0002771	71.10	silver quality
thymus	UBERON:0002370	70.31	silver quality
globus pallidus	UBERON:0001875	69.86	silver quality
left ventricle myocardium	UBERON:0006566	69.63	gold quality
cardiac muscle of right atrium	UBERON:0003379	69.61	gold quality
medial globus pallidus	UBERON:0002477	69.38	silver quality
visceral pleura	UBERON:0002401	68.62	gold quality
primary visual cortex	UBERON:0002436	68.46	silver quality
kidney epithelium	UBERON:0004819	67.24	gold quality
lung	UBERON:0002048	67.15	silver quality
occipital lobe	UBERON:0002021	66.97	silver quality
corpus callosum	UBERON:0002336	66.65	silver quality
subthalamic nucleus	UBERON:0001906	66.56	silver quality
pharyngeal mucosa	UBERON:0000355	66.43	silver quality
amygdala	UBERON:0001876	66.41	gold quality
body of tongue	UBERON:0011876	66.20	silver quality
Brodmann (1909) area 23	UBERON:0013554	66.16	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MicroRNA-374c-5p inhibits the development of breast cancer through TATA-box binding protein associated factor 7-mediated transcriptional regulation of DEP domain containing 1. (PMID:31162714)
• miR374c5p regulates PTTG1 and inhibits cell growth and metastasis in hepatocellular carcinoma by regulating epithelialmesenchymal transition. (PMID:35234260)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.