MIR376A1

Summary

MIR376A1 (microRNA 376a-1, HGNC:31869) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 494325 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31869
Approved symbol	MIR376A1
Name	microRNA 376a-1
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-376a, hsa-mir-376a-1
Ensembl gene	ENSG00000283588
Ensembl biotype	miRNA
OMIM	610959
Entrez	494325
RNAcentral	URS000075B4B1 — miRNA, 68 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616574

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616574 — 1 exons

Exon	Start	End
ENSE00003743484	101040782	101040849

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 82.08.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.08	gold quality
colon	UBERON:0001155	80.00	gold quality
adrenal tissue	UBERON:0018303	77.76	gold quality
adrenal gland	UBERON:0002369	76.20	gold quality
placenta	UBERON:0001987	76.09	gold quality
islet of Langerhans	UBERON:0000006	74.17	gold quality
lung	UBERON:0002048	73.48	gold quality
left adrenal gland cortex	UBERON:0035825	71.89	gold quality
body of pancreas	UBERON:0001150	71.23	gold quality
blood	UBERON:0000178	69.93	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.59	gold quality
ascending aorta	UBERON:0001496	68.63	gold quality
Ammon’s horn	UBERON:0001954	68.08	gold quality
anterior cingulate cortex	UBERON:0009835	67.81	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.76	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.21	gold quality
omental fat pad	UBERON:0010414	65.82	gold quality
putamen	UBERON:0001874	64.73	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.71	gold quality
substantia nigra	UBERON:0002038	63.58	gold quality
cerebellar hemisphere	UBERON:0002245	63.29	gold quality
skin of abdomen	UBERON:0001416	63.17	gold quality
nucleus accumbens	UBERON:0001882	63.07	gold quality
spleen	UBERON:0002106	62.53	gold quality
Brodmann (1909) area 9	UBERON:0013540	62.53	gold quality
left ovary	UBERON:0002119	62.41	gold quality
stomach	UBERON:0000945	62.19	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.18	gold quality
hypothalamus	UBERON:0001898	61.72	gold quality
adenohypophysis	UBERON:0002196	61.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 26)

• The miR-376a is significantly down-regulated and CDK2 is released from miR-376a inhibition, thereby facilitating the escape of progenitor cells from the quiescent state into erythroid differentiation. (PMID:21556037)
• miR-376a may contribute to the development of hepatocellular carcinoma by targeting p85alpha (PMID:22684007)
• down-regulation of mir-376a and mir-376c may contribute to IGF1R over-expression and to aberrant negative regulation of this signaling pathway in melanoma, thus promoting tumorigenesis and metastasis. (PMID:22747855)
• Overexpression of miR-376a is associated with inhibition of arsenic trioxide induced apoptosis in retinoblastoma. (PMID:23373993)
• Mir-376a, mapped to the 14q32.31 locus, regulates proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. (PMID:24166498)
• Circulating miR-127-3p, miR-376a and miR-652 were found to be associated with breast cancer. (PMID:24194846)
• Our findings underline the importance of miRNAs encoded by the DLK1/GTL2 gene cluster in stress-response control mechanisms, and introduce MIR376A as a new regulator of autophagy. (PMID:24358205)
• High miR-376a expression is associated with aggressive lung adenocarcinoma. (PMID:24833665)
• Serum miR-376a may serve as a potential noninvasive biomarker in detecting macrosomia. (PMID:25405200)
• Data show that miR-376a and HDAC9 expression are inversely correlated in hepatocellular carcinoma and suggest that HDAC9-mediated epigenetic modification may contribute to the down-regulation of the miR-376 cluster in hepatocellular carcinoma. (PMID:25613642)
• Results suggest a long non-coding RNA MALAT1/MIR376A/transforming growth factor alpha (TGFA) axis mediates osteosarcoma (OS) cell proliferation and tumor progression. (PMID:27458156)
• A diagnostic four-microRNA signature consisting of miR-23a-3p, miR-27a-3p, miR-142-5p and miR-376c-3p was established (AUC = 0.917), distinguishing colon cancer patients from healthy donors with sensitivity of 89% and specificity of 81% (AUC = 0.922). This panel of microRNAs exhibited high diagnostic performance also when analyzed separately in colon cancer patients in early stages of the disease (PMID:27485599)
• This study demonstrated that hsa-miR-376c-3p plays an important role in the inhibition of gastric tumor growth and tumor related gene expression both in vitro and in vivo. (PMID:27965982)
• Decreased serum miR-376a is associated with glioma. (PMID:28211798)
• In the present study, specificity protein 1 (SP1) was demonstrated to be a direct target of miR-376a. (PMID:29257212)
• Reduced miR376a expression is associated with the mechanism underlying osteosarcoma progression. (PMID:30085330)
• Bioinformatics analysis found that miR-376a was downregulated in gastric cancer (GC) tissues. Compared with the control group, RT-qPCR results showed that the expression of miR-376a in GC cell lines and tissues were also significantly decreased. (PMID:30522118)
• MiR-376a functions as tumor suppressor by targeting SGK3 in renal cell carcinoma. (PMID:31114998)
• Modified level of miR-376a is associated with Parkinson’s disease. (PMID:31930701)
• LncRNA NUTM2A-AS1 positively modulates TET1 and HIF-1A to enhance gastric cancer tumorigenesis and drug resistance by sponging miR-376a. (PMID:33089970)
• circPGAM1 enhances autophagy signaling during laryngocarcinoma drug resistance by regulating miR-376a. (PMID:33121682)
• MiR-376a-3p alleviates the development of glioma through negatively regulating KLF15. (PMID:33275234)
• Pseudogene Annexin A2 Pseudogene 1 Contributes to Hepatocellular Carcinoma Progression by Modulating Its Parental Gene ANXA2 via miRNA-376a-3p. (PMID:33398718)
• Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4gamma2 axis. (PMID:35196197)
• MiR-376a-3p increases cell apoptosis in acute myeloid leukemia by targeting MT1X. (PMID:35316152)
• TRIM36 enhances lung adenocarcinoma radiosensitivity and inhibits tumorigenesis through promoting RAD51 ubiquitination and antagonizing hsa-miR-376a-5p. (PMID:36058131)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.