MIR376A2

Summary

MIR376A2 (microRNA 376a-2, HGNC:32532) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 664615 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32532
Approved symbol	MIR376A2
Name	microRNA 376a-2
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-376a-2
Ensembl gene	ENSG00000283561
Ensembl biotype	miRNA
OMIM	610960
Entrez	664615
RNAcentral	URS00006E23D8 — miRNA, 80 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636782

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636782 — 1 exons

Exon	Start	End
ENSE00003797664	101040069	101040148

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 96.21.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.21	gold quality
adrenal tissue	UBERON:0018303	87.37	gold quality
monocyte	CL:0000576	84.14	gold quality
placenta	UBERON:0001987	80.13	gold quality
lung	UBERON:0002048	78.86	gold quality
tibial nerve	UBERON:0001323	77.29	gold quality
heart	UBERON:0000948	76.69	gold quality
stomach	UBERON:0000945	76.56	gold quality
islet of Langerhans	UBERON:0000006	76.02	gold quality
body of stomach	UBERON:0001161	74.36	gold quality
right lobe of liver	UBERON:0001114	71.96	gold quality
intestine	UBERON:0000160	70.38	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.20	gold quality
tibial artery	UBERON:0007610	69.82	gold quality
colon	UBERON:0001155	69.66	gold quality
liver	UBERON:0002107	69.39	gold quality
endometrium	UBERON:0001295	68.59	gold quality
left ovary	UBERON:0002119	68.51	gold quality
amygdala	UBERON:0001876	68.05	gold quality
omental fat pad	UBERON:0010414	67.98	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.66	gold quality
left adrenal gland cortex	UBERON:0035825	66.82	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.27	gold quality
transverse colon	UBERON:0001157	65.51	gold quality
hypothalamus	UBERON:0001898	65.02	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.13	gold quality
minor salivary gland	UBERON:0001830	63.97	gold quality
substantia nigra	UBERON:0002038	63.05	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.96	gold quality
vagina	UBERON:0000996	62.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR-376a may contribute to the development of hepatocellular carcinoma by targeting p85alpha (PMID:22684007)
• Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4gamma2 axis. (PMID:35196197)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.