MIR376B

Summary

MIR376B (microRNA 376b, HGNC:32066) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574435 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32066
Approved symbol	MIR376B
Name	microRNA 376b
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-376b
Ensembl gene	ENSG00000283556
Ensembl biotype	miRNA
OMIM	610961
Entrez	574435
RNAcentral	URS000075A7C0 — miRNA, 100 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614515

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614515 — 1 exons

Exon	Start	End
ENSE00003740918	101040436	101040535

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 97.96.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	97.96	gold quality
sural nerve	UBERON:0015488	88.60	gold quality
stomach	UBERON:0000945	85.05	gold quality
blood	UBERON:0000178	84.03	gold quality
kidney	UBERON:0002113	80.04	gold quality
lung	UBERON:0002048	79.40	gold quality
intestine	UBERON:0000160	79.18	gold quality
placenta	UBERON:0001987	78.59	gold quality
colon	UBERON:0001155	77.48	gold quality
calcaneal tendon	UBERON:0003701	77.01	gold quality
vagina	UBERON:0000996	75.88	gold quality
liver	UBERON:0002107	75.51	gold quality
monocyte	CL:0000576	75.44	gold quality
adult mammalian kidney	UBERON:0000082	74.91	gold quality
islet of Langerhans	UBERON:0000006	74.06	gold quality
body of pancreas	UBERON:0001150	73.06	gold quality
gastrocnemius	UBERON:0001388	72.96	gold quality
endometrium	UBERON:0001295	72.75	gold quality
saliva-secreting gland	UBERON:0001044	72.44	gold quality
heart	UBERON:0000948	71.19	gold quality
body of stomach	UBERON:0001161	70.81	gold quality
ascending aorta	UBERON:0001496	70.67	gold quality
thoracic aorta	UBERON:0001515	70.63	gold quality
left adrenal gland	UBERON:0001234	70.10	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.82	gold quality
minor salivary gland	UBERON:0001830	69.21	gold quality
left ovary	UBERON:0002119	68.68	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.54	gold quality
right adrenal gland cortex	UBERON:0035827	68.52	gold quality
right adrenal gland	UBERON:0001233	68.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• miR-376b controls autophagy by directly regulating intracellular levels of two key autophagy proteins, ATG4C and BECN1. (PMID:22248718)
• Expression of miR-154*, miR-376b, and miR-431* were suppressed in leukocytes from initial Grave disease patients. (PMID:22456620)
• MiR376b5p repressed angiogenesis in vivo and in vitro, and miR376b5p inhibited angiogenesis in HUVECs by targeting the HIF1alphamediated VEGFA/Notch1 signaling pathway. (PMID:24789343)
• LncRNA NEAT1 regulated cell proliferation, invasion, migration and apoptosis by targeting has-miR-376b-3p/SULF1 axis in non-small cell lung cancer. (PMID:32432744)
• [Study on the expression of non-coding microRNA-376b-3p in serum exosomes of patients with malignant glioma and the mechanism of anti-angiogenesis]. (PMID:32486598)
• MiR-376b-3p functions as a tumor suppressor by targeting KLF15 in non-small cell lung cancer. (PMID:33015790)
• Long noncoding RNA MAPKAPK5-AS1 promotes metastasis through regulation miR-376b-5p/ECT2 axis in hepatocellular carcinoma. (PMID:36567178)
• MicroRNA-376b is involved in the pathogenesis of thyroid-associated ophthalmopathy by regulating HAS2. (PMID:37231239)
• LINC01980 induced by TGF-beta promotes hepatocellular carcinoma metastasis via miR-376b-5p/E2F5 axis. (PMID:37827344)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.