MIR376C

Summary

MIR376C (microRNA 376c, HGNC:31782) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 442913 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31782
Approved symbol	MIR376C
Name	microRNA 376c
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-368, hsa-mir-376c
Ensembl gene	ENSG00000283279
Ensembl biotype	miRNA
OMIM	610983
Entrez	442913
RNAcentral	URS000075AAAD — miRNA, 66 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000607441

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000607441 — 1 exons

Exon	Start	End
ENSE00003699182	101039690	101039755

Expression profiles

Bgee: expression breadth broad, 52 present calls, max score 82.75.

Top tissues by expression

52 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	82.75	gold quality
adrenal tissue	UBERON:0018303	82.32	gold quality
heart	UBERON:0000948	80.88	gold quality
calcaneal tendon	UBERON:0003701	80.51	gold quality
lung	UBERON:0002048	79.10	gold quality
muscle of leg	UBERON:0001383	78.56	gold quality
left adrenal gland cortex	UBERON:0035825	73.30	gold quality
gastrocnemius	UBERON:0001388	73.27	gold quality
islet of Langerhans	UBERON:0000006	72.12	gold quality
intestine	UBERON:0000160	71.77	gold quality
putamen	UBERON:0001874	71.66	gold quality
Ammon’s horn	UBERON:0001954	69.63	gold quality
blood	UBERON:0000178	69.40	gold quality
colon	UBERON:0001155	69.23	gold quality
left adrenal gland	UBERON:0001234	69.08	gold quality
esophagus mucosa	UBERON:0002469	69.04	gold quality
caudate nucleus	UBERON:0001873	68.43	gold quality
right lobe of liver	UBERON:0001114	68.40	gold quality
liver	UBERON:0002107	68.35	gold quality
ascending aorta	UBERON:0001496	68.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.55	gold quality
substantia nigra	UBERON:0002038	67.12	gold quality
skin of leg	UBERON:0001511	65.95	gold quality
right frontal lobe	UBERON:0002810	65.82	gold quality
frontal lobe	UBERON:0016525	65.81	gold quality
tibial artery	UBERON:0007610	65.65	gold quality
ovary	UBERON:0000992	65.19	gold quality
left ovary	UBERON:0002119	65.19	gold quality
brain	UBERON:0000955	65.18	gold quality
renal glomerulus	UBERON:0000074	65.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 24)

• miR-376c promotes ovarian cancer cell proliferation,survival and spheroid formation (PMID:21224400)
• down-regulation of mir-376a and mir-376c may contribute to IGF1R over-expression and to aberrant negative regulation of this signaling pathway in melanoma, thus promoting tumorigenesis and metastasis. (PMID:22747855)
• Upregulation of plasma MIR376C is associated with breast cancer. (PMID:22927033)
• the role of miR-376c in regulating osteosarcoma cell growth via miR-376c/TGF-alpha axis (PMID:23631646)
• Epigenetic repression of miR-376c accelerated EGF-dependent cell migration through its target GRB2 in HuCCT1 cells. (PMID:23922722)
• Mir-376c, mapped to the 14q32.31 locus, regulates proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. (PMID:24166498)
• miR-376c levels were differentially expressed by race and PAR4 reactivity and were inversely correlated with PCTP mRNA levels, PC-TP protein levels and PAR4 reactivity. (PMID:24216752)
• microRNA 376c (miR-376c) significantly enhanced neural differentiation of hPSCs in a defined condition by suppressing SMAD4 (PMID:25114173)
• miR-638 plays an important role in triple-negative breast cancer progression via BRCA1 deregulation. (PMID:25228385)
• Expression of UGT2B15 and UGT2B17 is negatively regulated by the binding of miR-376c. (PMID:26163549)
• miR-376c is inversely linked to UGT2B15 and UGT2B17 expression in high-grade prostate cancer and metastasis.UGT2B15 and UGT2B17 genes are direct targets of miR-376c and thus may influence steroid metabolism during prostate cancer progression. (PMID:26385605)
• miR-376c inhibits non-small-cell lung cancer cell growth and invasion by targeting LRH-1 (PMID:27049310)
• newly identified miR-376c/BMI1 pathway provides an insight into cervical cancer progression (PMID:27345009)
• our results defined a novel pathway in which dysregulation of the RUNX2/INHBA axis due to miR-376c downregulation fosters lymph node metastasis in head and neck squamous cell carcinoma (PMID:27760788)
• TSP-2 enhances the migration of PCa cells by increasing MMP-2 expression through down-regulation of miR-376c expression. (PMID:28122633)
• MiR-376c-3p suppresses the fission, proliferation, migration and invasion and induces cell apoptosis of oral squamous cancer cells via targeting HOXB7. (PMID:28482289)
• results demonstrate that miR-376c functions by suppressing ARID4A expression, which in turn enhances the oncogenicity of gastric carcinoma cells. It seems likely that the level of miR-376c in plasma and urine could act as invaluable markers for the detection of gastric carcinoma (PMID:28486502)
• over-expression of miR-638 inhibited the activation of Wnt/beta-catenin signaling pathway. (PMID:29271990)
• that DLX6-AS1 may contribute to preeclampsia by impairing proliferative, migratory and invasive abilities of trophoblasts via the miR-376c/GADD45A axis (PMID:30055134)
• we have identified miR-376c-3p as a TWIST-1-regulated miRNA, which plays an important role in the osteogenesis of bone precursor cells and can mediate TWIST-1 inhibition of osteogenesis. (PMID:30229694)
• The data suggest that miR-376c-3p downregulated ING5 to exert protective effects against oxygen-glucose deprivation-induced cell injury in cultured human and rat cells. (PMID:31844418)
• Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes. (PMID:32357971)
• CircEXOC6B Suppresses the Proliferation and Motility and Sensitizes Ovarian Cancer Cells to Paclitaxel Through miR-376c-3p/FOXO3 Axis. (PMID:33006481)
• Loading MicroRNA-376c in Extracellular Vesicles Inhibits Properties of Non-Small Cell Lung Cancer Cells by Targeting YTHDF1. (PMID:33280517)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.