MIR378B

Summary

MIR378B (microRNA 378b, HGNC:38283) is a microRNA gene on chromosome 3p25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422933 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38283
Approved symbol	MIR378B
Name	microRNA 378b
Location	3p25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-378b
Ensembl gene	ENSG00000264534
Ensembl biotype	miRNA
Entrez	100422933
RNAcentral	URS000075E326 — ncRNA, 57 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578876

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578876 — 1 exons

Exon	Start	End
ENSE00002695084	10330229	10330285

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 95.10.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	95.10	gold quality
skeletal muscle tissue	UBERON:0001134	94.71	gold quality
cerebellar hemisphere	UBERON:0002245	93.12	gold quality
prefrontal cortex	UBERON:0000451	91.71	gold quality
right uterine tube	UBERON:0001302	89.40	gold quality
right lobe of liver	UBERON:0001114	89.32	gold quality
liver	UBERON:0002107	88.18	gold quality
muscle of leg	UBERON:0001383	81.30	gold quality
frontal cortex	UBERON:0001870	80.33	gold quality
right frontal lobe	UBERON:0002810	80.11	gold quality
Brodmann (1909) area 9	UBERON:0013540	78.91	gold quality
gastrocnemius	UBERON:0001388	78.52	gold quality
lymph node	UBERON:0000029	78.25	gold quality
left uterine tube	UBERON:0001303	77.87	gold quality
brain	UBERON:0000955	77.68	gold quality
fallopian tube	UBERON:0003889	77.19	gold quality
cerebral cortex	UBERON:0000956	77.04	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	76.89	gold quality
endometrium	UBERON:0001295	76.14	gold quality
blood	UBERON:0000178	76.02	gold quality
anterior cingulate cortex	UBERON:0009835	75.91	gold quality
right adrenal gland	UBERON:0001233	75.90	gold quality
smooth muscle tissue	UBERON:0001135	75.80	gold quality
saliva-secreting gland	UBERON:0001044	75.77	gold quality
heart left ventricle	UBERON:0002084	75.19	gold quality
multicellular organism	UBERON:0000468	73.99	gold quality
nucleus accumbens	UBERON:0001882	73.59	gold quality
minor salivary gland	UBERON:0001830	73.44	gold quality
myometrium	UBERON:0001296	73.41	gold quality
amygdala	UBERON:0001876	73.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Results indicate that miR-378 may serve as a tumor suppressor and play an important role in inhibiting glioma cell migration and invasion. (PMID:26261592)
• miR-378 regulates the angiogenic capacity of CD34(+) progenitor cells in STEMI patients. (PMID:28062497)
• miR378b represses the mRNA expression levels of COL1A1 via interference with SIRT6 in human dermal fibroblasts. (PMID:28983623)
• Serum exosomal miR-378 upregulation is associated with poor prognosis in non-small-cell lung cancer patients. (PMID:32061007)
• Upregulated lncRNA Cyclin-dependent kinase inhibitor 2B antisense RNA 1 induces the proliferation and migration of colorectal cancer by miR-378b/CAPRIN2 axis. (PMID:34511033)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm54396	ENSMUSG00002075787
rattus_norvegicus	Mir3557	ENSRNOG00000035517

Paralogs (2): MIR378A (ENSG00000199047), MIR378D2 (ENSG00000284288)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.