MIR378C

Summary

MIR378C (microRNA 378c, HGNC:38374) is a microRNA gene on chromosome 10q26.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422867 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38374
Approved symbol	MIR378C
Name	microRNA 378c
Location	10q26.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-378c
Ensembl gene	ENSG00000264803
Ensembl biotype	miRNA
Entrez	100422867
RNAcentral	URS000075ABA6 — miRNA, 81 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578683

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578683 — 1 exons

Exon	Start	End
ENSE00002709135	130962588	130962668

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 80.73.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.73	gold quality
right lobe of liver	UBERON:0001114	64.58	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.40	gold quality
tibial nerve	UBERON:0001323	61.38	gold quality
lung	UBERON:0002048	58.96	gold quality
right frontal lobe	UBERON:0002810	55.93	gold quality
pituitary gland	UBERON:0000007	55.44	gold quality
testis	UBERON:0000473	43.94	gold quality
left testis	UBERON:0004533	43.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Results indicate that miR-378 may serve as a tumor suppressor and play an important role in inhibiting glioma cell migration and invasion. (PMID:26261592)
• miR-378 regulates the angiogenic capacity of CD34(+) progenitor cells in STEMI patients. (PMID:28062497)
• The lncRNA PVT1 promotes invasive growth of lung adenocarcinoma cells by targeting miR-378c to regulate SLC2A1 expression. (PMID:32960438)
• miR-378c suppresses Wilms tumor development via negatively regulating CAMKK2. (PMID:33956079)
• The miR-378c-Samd1 circuit promotes phenotypic modulation of vascular smooth muscle cells and foam cells formation in atherosclerosis lesions. (PMID:34006929)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.