MIR378D1

Summary

MIR378D1 (microRNA 378d-1, HGNC:41550) is a microRNA gene on chromosome 4p16.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616201 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41550
Approved symbol	MIR378D1
Name	microRNA 378d-1
Location	4p16.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-378d-1
Ensembl gene	ENSG00000263631
Ensembl biotype	miRNA
Entrez	100616201
RNAcentral	URS0000759B21 — miRNA, 54 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580913

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580913 — 1 exons

Exon	Start	End
ENSE00002687610	5923275	5923328

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 83.63.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.63	gold quality
hypothalamus	UBERON:0001898	76.13	gold quality
amygdala	UBERON:0001876	74.09	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.09	gold quality
body of pancreas	UBERON:0001150	72.34	gold quality
blood	UBERON:0000178	71.82	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.95	gold quality
ascending aorta	UBERON:0001496	68.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.29	gold quality
putamen	UBERON:0001874	67.07	gold quality
nucleus accumbens	UBERON:0001882	66.47	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.46	gold quality
Ammon’s horn	UBERON:0001954	66.44	gold quality
caudate nucleus	UBERON:0001873	65.86	gold quality
cerebellar hemisphere	UBERON:0002245	65.67	gold quality
right frontal lobe	UBERON:0002810	64.75	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.28	gold quality
testis	UBERON:0000473	51.22	gold quality
left testis	UBERON:0004533	49.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-378d is Involved in the Regulation of Apoptosis and Autophagy of and E2 Secretion from Cultured Ovarian Granular Cells Treated by Sodium Fluoride. (PMID:33405077)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.