MIR378D2

Summary

MIR378D2 (microRNA 378d-2, HGNC:41797) is a microRNA gene on chromosome 8q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616169 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41797
Approved symbol	MIR378D2
Name	microRNA 378d-2
Location	8q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-378d-2
Ensembl gene	ENSG00000284288
Ensembl biotype	miRNA
Entrez	100616169
RNAcentral	URS000075A8D8 — ncRNA, 98 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580636

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580636 — 1 exons

Exon	Start	End
ENSE00002710237	93916022	93916119

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 76.66.

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of stomach	UBERON:0001161	76.66	gold quality
right lobe of thyroid gland	UBERON:0001119	76.51	gold quality
blood	UBERON:0000178	72.77	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.63	gold quality
lower esophagus mucosa	UBERON:0035834	68.44	gold quality
esophagus mucosa	UBERON:0002469	66.60	gold quality
left adrenal gland cortex	UBERON:0035825	66.46	gold quality
nucleus accumbens	UBERON:0001882	66.39	gold quality
right atrium auricular region	UBERON:0006631	66.15	gold quality
left adrenal gland	UBERON:0001234	65.88	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.44	gold quality
vagina	UBERON:0000996	63.47	gold quality
skin of abdomen	UBERON:0001416	63.12	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.03	gold quality
ascending aorta	UBERON:0001496	61.71	gold quality
caudate nucleus	UBERON:0001873	61.69	gold quality
Ammon’s horn	UBERON:0001954	61.39	gold quality
omental fat pad	UBERON:0010414	61.06	gold quality
pituitary gland	UBERON:0000007	60.56	gold quality
transverse colon	UBERON:0001157	60.10	gold quality
thyroid gland	UBERON:0002046	59.45	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	55.48	gold quality
adult mammalian kidney	UBERON:0000082	51.76	gold quality
left testis	UBERON:0004533	42.49	gold quality
right testis	UBERON:0004534	27.36	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-378d is Involved in the Regulation of Apoptosis and Autophagy of and E2 Secretion from Cultured Ovarian Granular Cells Treated by Sodium Fluoride. (PMID:33405077)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm54396	ENSMUSG00002075787
rattus_norvegicus	Mir3557	ENSRNOG00000035517

Paralogs (2): MIR378A (ENSG00000199047), MIR378B (ENSG00000264534)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.