MIR378E

Summary

MIR378E (microRNA 378e, HGNC:41671) is a microRNA gene on chromosome 5q35.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616498 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41671
Approved symbol	MIR378E
Name	microRNA 378e
Location	5q35.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-378e
Ensembl gene	ENSG00000263831
Ensembl biotype	miRNA
Entrez	100616498
RNAcentral	URS000075DCAA — miRNA, 79 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581976

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581976 — 1 exons

Exon	Start	End
ENSE00002700257	170028488	170028566

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 84.44.

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	84.44	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.11	gold quality
blood	UBERON:0000178	78.93	gold quality
anterior cingulate cortex	UBERON:0009835	76.21	gold quality
monocyte	CL:0000576	75.75	gold quality
liver	UBERON:0002107	75.46	gold quality
stomach	UBERON:0000945	70.53	gold quality
adult mammalian kidney	UBERON:0000082	70.29	gold quality
gall bladder	UBERON:0002110	67.21	gold quality
heart	UBERON:0000948	66.78	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.45	gold quality
thoracic aorta	UBERON:0001515	65.85	gold quality
ascending aorta	UBERON:0001496	65.43	gold quality
gastrocnemius	UBERON:0001388	65.40	gold quality
tibial artery	UBERON:0007610	65.21	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.00	gold quality
body of stomach	UBERON:0001161	64.98	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.85	gold quality
transverse colon	UBERON:0001157	64.69	gold quality
colon	UBERON:0001155	64.48	gold quality
left coronary artery	UBERON:0001626	64.47	gold quality
skin of leg	UBERON:0001511	64.02	gold quality
left adrenal gland cortex	UBERON:0035825	63.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.59	gold quality
cerebellar hemisphere	UBERON:0002245	63.38	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.33	gold quality
omental fat pad	UBERON:0010414	63.03	gold quality
left adrenal gland	UBERON:0001234	62.72	gold quality
minor salivary gland	UBERON:0001830	62.70	gold quality
right frontal lobe	UBERON:0002810	62.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Knockdown of circNFIX inhibits progression of glioma in vitro and in vivo by increasing miR-378e and decreasing RPN2, providing a novel mechanism for understanding the pathogenesis of glioma. (PMID:31888753)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.