MIR378F

Summary

MIR378F (microRNA 378f, HGNC:41686) is a microRNA gene on chromosome 1p36.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616492 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41686
Approved symbol	MIR378F
Name	microRNA 378f
Location	1p36.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-378f
Ensembl gene	ENSG00000264926
Ensembl biotype	miRNA
Entrez	100616492
RNAcentral	URS000075C7A2 — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578143

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578143 — 1 exons

Exon	Start	End
ENSE00002688141	23929070	23929147

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 72.11.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	72.11	gold quality
blood	UBERON:0000178	69.61	gold quality
skin of leg	UBERON:0001511	63.20	gold quality
cerebellar hemisphere	UBERON:0002245	62.24	gold quality
prostate gland	UBERON:0002367	61.16	gold quality
spleen	UBERON:0002106	58.69	gold quality
left lobe of thyroid gland	UBERON:0001120	58.45	gold quality
testis	UBERON:0000473	45.16	gold quality
left testis	UBERON:0004533	44.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.34

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.