MIR378G

Summary

MIR378G (microRNA 378g, HGNC:41785) is a microRNA gene on chromosome 1p21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616321 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41785
Approved symbol	MIR378G
Name	microRNA 378g
Location	1p21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-378g
Ensembl gene	ENSG00000263526
Ensembl biotype	miRNA
Entrez	100616321
RNAcentral	URS000075E764 — ncRNA, 41 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579876

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579876 — 1 exons

Exon	Start	End
ENSE00002687356	94745860	94745900

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 87.73.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	87.73	gold quality
monocyte	CL:0000576	83.02	gold quality
kidney	UBERON:0002113	82.56	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.42	gold quality
adult mammalian kidney	UBERON:0000082	81.13	gold quality
myometrium	UBERON:0001296	79.29	gold quality
blood	UBERON:0000178	77.86	gold quality
body of pancreas	UBERON:0001150	77.51	gold quality
stomach	UBERON:0000945	76.66	gold quality
liver	UBERON:0002107	76.63	gold quality
placenta	UBERON:0001987	76.12	gold quality
adrenal gland	UBERON:0002369	75.53	gold quality
rectum	UBERON:0001052	75.38	gold quality
body of stomach	UBERON:0001161	74.98	gold quality
colon	UBERON:0001155	74.53	gold quality
transverse colon	UBERON:0001157	74.50	gold quality
heart	UBERON:0000948	74.43	gold quality
left coronary artery	UBERON:0001626	74.05	gold quality
intestine	UBERON:0000160	73.96	gold quality
minor salivary gland	UBERON:0001830	73.53	gold quality
heart left ventricle	UBERON:0002084	73.17	gold quality
fundus of stomach	UBERON:0001160	72.96	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.96	gold quality
thoracic aorta	UBERON:0001515	72.55	gold quality
lung	UBERON:0002048	72.24	gold quality
substantia nigra	UBERON:0002038	72.13	gold quality
left adrenal gland	UBERON:0001234	71.69	gold quality
left adrenal gland cortex	UBERON:0035825	71.67	gold quality
metanephros cortex	UBERON:0010533	71.56	gold quality
tibial artery	UBERON:0007610	71.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• MiR-378g enhanced radiosensitivity partially by targeting SHP-1 in NPC cells. (PMID:26473472)
• HOXC13-AS accelerates cell proliferation and migration in oral squamous cell carcinoma via miR-378g/HOXC13 axis. (PMID:32763778)
• LncRNA JPX contributes to Treg/Th17 imbalance in allergic rhinitis via targeting the miR-378g/CCL5 axis. (PMID:35387544)
• FOXD2-AS1 promotes malignant cell behavior in oral squamous cell carcinoma via the miR-378 g/CRABP2 axis. (PMID:38807101)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.