MIR378H

Summary

MIR378H (microRNA 378h, HGNC:41744) is a microRNA gene on chromosome 5q33.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616306 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41744
Approved symbol	MIR378H
Name	microRNA 378h
Location	5q33.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-378h
Ensembl gene	ENSG00000263361
Ensembl biotype	miRNA
Entrez	100616306
RNAcentral	URS000075C7AC — miRNA, 83 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579966

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579966 — 1 exons

Exon	Start	End
ENSE00002723694	154829458	154829540

Expression profiles

Bgee: expression breadth ubiquitous, 115 present calls, max score 99.61.

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	99.61	gold quality
skeletal muscle tissue	UBERON:0001134	90.30	gold quality
right uterine tube	UBERON:0001302	90.22	gold quality
calcaneal tendon	UBERON:0003701	89.94	gold quality
corpus callosum	UBERON:0002336	88.67	gold quality
sural nerve	UBERON:0015488	88.15	gold quality
adrenal tissue	UBERON:0018303	87.97	gold quality
endometrium	UBERON:0001295	87.64	gold quality
apex of heart	UBERON:0002098	84.20	gold quality
bone marrow	UBERON:0002371	83.77	gold quality
smooth muscle tissue	UBERON:0001135	82.21	gold quality
descending thoracic aorta	UBERON:0002345	81.81	gold quality
vermiform appendix	UBERON:0001154	81.56	gold quality
tibial nerve	UBERON:0001323	81.39	gold quality
liver	UBERON:0002107	81.24	gold quality
prefrontal cortex	UBERON:0000451	81.17	gold quality
placenta	UBERON:0001987	80.70	gold quality
right adrenal gland cortex	UBERON:0035827	80.69	gold quality
saliva-secreting gland	UBERON:0001044	80.36	gold quality
minor salivary gland	UBERON:0001830	80.01	gold quality
right ovary	UBERON:0002118	79.24	gold quality
muscle of leg	UBERON:0001383	78.99	gold quality
left adrenal gland cortex	UBERON:0035825	78.89	gold quality
metanephros cortex	UBERON:0010533	78.80	gold quality
adrenal gland	UBERON:0002369	78.78	gold quality
subcutaneous adipose tissue	UBERON:0002190	78.71	gold quality
right adrenal gland	UBERON:0001233	78.63	gold quality
right lung	UBERON:0002167	78.60	gold quality
myometrium	UBERON:0001296	78.46	gold quality
right lobe of thyroid gland	UBERON:0001119	78.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.80

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.