MIR378I

Summary

MIR378I (microRNA 378i, HGNC:41620) is a microRNA gene on chromosome 22q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616259 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41620
Approved symbol	MIR378I
Name	microRNA 378i
Location	22q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-378i
Ensembl gene	ENSG00000283829
Ensembl biotype	miRNA
Entrez	100616259
RNAcentral	URS000075DA4C — miRNA, 76 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582688

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582688 — 1 exons

Exon	Start	End
ENSE00002693665	41923222	41923297

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 76.36.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	76.36	gold quality
gastrocnemius	UBERON:0001388	72.16	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	70.42	gold quality
blood	UBERON:0000178	69.31	gold quality
right lobe of liver	UBERON:0001114	68.61	gold quality
Ammon’s horn	UBERON:0001954	66.21	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.93	gold quality
tibial artery	UBERON:0007610	65.02	gold quality
right atrium auricular region	UBERON:0006631	64.53	gold quality
body of pancreas	UBERON:0001150	64.50	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.41	gold quality
stomach	UBERON:0000945	64.30	gold quality
left coronary artery	UBERON:0001626	63.95	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.91	gold quality
ascending aorta	UBERON:0001496	63.72	gold quality
body of stomach	UBERON:0001161	63.06	gold quality
hypothalamus	UBERON:0001898	62.96	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	61.23	gold quality
tibial nerve	UBERON:0001323	61.00	gold quality
omental fat pad	UBERON:0010414	60.99	gold quality
esophagus mucosa	UBERON:0002469	60.22	gold quality
caudate nucleus	UBERON:0001873	59.04	gold quality
fundus of stomach	UBERON:0001160	58.73	gold quality
putamen	UBERON:0001874	57.65	gold quality
transverse colon	UBERON:0001157	57.53	gold quality
left adrenal gland	UBERON:0001234	55.91	gold quality
prostate gland	UBERON:0002367	54.16	gold quality
right lobe of thyroid gland	UBERON:0001119	53.58	gold quality
thyroid gland	UBERON:0002046	51.43	gold quality
pituitary gland	UBERON:0000007	51.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.