MIR378J

Summary

MIR378J (microRNA 378j, HGNC:49979) is a microRNA gene on chromosome 17q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465136 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49979
Approved symbol	MIR378J
Name	microRNA 378j
Location	17q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-378j
Ensembl gene	ENSG00000274620
Ensembl biotype	miRNA
Entrez	102465136
RNAcentral	URS000075C0D8 — ncRNA, 109 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611988

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611988 — 1 exons

Exon	Start	End
ENSE00003737880	37614931	37615039

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 99.23.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	99.23	gold quality
endometrium	UBERON:0001295	92.48	gold quality
bone marrow	UBERON:0002371	91.50	gold quality
lower esophagus mucosa	UBERON:0035834	87.34	gold quality
monocyte	CL:0000576	85.78	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.52	gold quality
leukocyte	CL:0000738	85.33	gold quality
ectocervix	UBERON:0012249	84.91	gold quality
mucosa of stomach	UBERON:0001199	84.90	gold quality
left uterine tube	UBERON:0001303	84.24	gold quality
right coronary artery	UBERON:0001625	83.38	gold quality
myometrium	UBERON:0001296	83.05	gold quality
fundus of stomach	UBERON:0001160	82.64	gold quality
left ovary	UBERON:0002119	82.63	gold quality
stomach	UBERON:0000945	82.56	gold quality
right ovary	UBERON:0002118	82.37	gold quality
small intestine Peyer’s patch	UBERON:0003454	82.35	gold quality
body of stomach	UBERON:0001161	82.25	gold quality
liver	UBERON:0002107	82.18	gold quality
right adrenal gland	UBERON:0001233	82.13	gold quality
small intestine	UBERON:0002108	81.87	gold quality
vagina	UBERON:0000996	81.82	gold quality
ovary	UBERON:0000992	81.75	gold quality
body of pancreas	UBERON:0001150	81.70	gold quality
body of uterus	UBERON:0009853	81.33	gold quality
right adrenal gland cortex	UBERON:0035827	81.29	gold quality
endocervix	UBERON:0000458	80.93	gold quality
right lobe of liver	UBERON:0001114	80.72	gold quality
esophagus mucosa	UBERON:0002469	80.60	gold quality
granulocyte	CL:0000094	80.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.