MIR380

Summary

MIR380 (microRNA 380, HGNC:31873) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 494329 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31873
Approved symbol	MIR380
Name	microRNA 380
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-380
Ensembl gene	ENSG00000198982
Ensembl biotype	miRNA
OMIM	613654
Entrez	494329
RNAcentral	URS000075D37E — miRNA, 61 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362112

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362112 — 1 exons

Exon	Start	End
ENSE00001436875	101025017	101025077

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 93.56.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	93.56	gold quality
stomach	UBERON:0000945	86.86	gold quality
kidney	UBERON:0002113	83.47	gold quality
calcaneal tendon	UBERON:0003701	82.91	gold quality
intestine	UBERON:0000160	81.88	gold quality
colon	UBERON:0001155	78.78	gold quality
heart	UBERON:0000948	77.28	gold quality
blood	UBERON:0000178	75.11	gold quality
lung	UBERON:0002048	73.21	gold quality
islet of Langerhans	UBERON:0000006	71.12	gold quality
vagina	UBERON:0000996	70.33	gold quality
anterior cingulate cortex	UBERON:0009835	69.89	gold quality
skin of leg	UBERON:0001511	69.87	gold quality
body of pancreas	UBERON:0001150	69.14	gold quality
endometrium	UBERON:0001295	69.10	gold quality
left adrenal gland cortex	UBERON:0035825	68.86	gold quality
omental fat pad	UBERON:0010414	68.51	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.36	gold quality
left adrenal gland	UBERON:0001234	68.00	gold quality
ascending aorta	UBERON:0001496	67.42	gold quality
amygdala	UBERON:0001876	67.12	gold quality
skin of abdomen	UBERON:0001416	67.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.02	gold quality
hypothalamus	UBERON:0001898	66.90	gold quality
left ovary	UBERON:0002119	66.60	gold quality
substantia nigra	UBERON:0002038	66.46	gold quality
Ammon’s horn	UBERON:0001954	66.31	gold quality
right frontal lobe	UBERON:0002810	66.12	gold quality
caudate nucleus	UBERON:0001873	64.96	gold quality
corpus callosum	UBERON:0002336	64.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• In vivo delivery of a miR-380-5p antagonist decreases tumor size in an orthotopic mouse model of neuroblastoma. (PMID:20871609)
• Results suggest that microRNAs miR-221-5p, miR-380-3p, miR-556-5p, miR-758-3p and miR-3074-3p are potential diagnostic biomarkers of lupus nephritis in patients with systemic lupus erythematosus (SLE). (PMID:27835701)
• High miR380 expression is associated with glioma. (PMID:29743236)
• Depletion of miR-380 mitigates human bronchial epithelial cells injury to improve chronic obstructive pulmonary disease through targeting CHRNA4. (PMID:31821848)
• MicroR-380-3p Reduces Sepsis-Induced Acute Kidney Injury via Regulating RAB1P to Restrain NF-kappaB Pathway. (PMID:38220171)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.