MIR381

Summary

MIR381 (microRNA 381, HGNC:31874) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 494330 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31874
Approved symbol	MIR381
Name	microRNA 381
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-381
Ensembl gene	ENSG00000199020
Ensembl biotype	miRNA
Entrez	494330
RNAcentral	URS000075A1A8 — miRNA, 75 nt, 25 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362150

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362150 — 1 exons

Exon	Start	End
ENSE00001436913	101045920	101045994

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 96.49.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	96.49	gold quality
stomach	UBERON:0000945	81.95	gold quality
monocyte	CL:0000576	81.59	gold quality
kidney	UBERON:0002113	77.90	gold quality
placenta	UBERON:0001987	76.65	gold quality
heart	UBERON:0000948	76.00	gold quality
lung	UBERON:0002048	74.99	gold quality
intestine	UBERON:0000160	74.34	gold quality
blood	UBERON:0000178	72.83	gold quality
calcaneal tendon	UBERON:0003701	72.78	gold quality
islet of Langerhans	UBERON:0000006	71.83	gold quality
colon	UBERON:0001155	70.36	gold quality
rectum	UBERON:0001052	68.70	gold quality
ascending aorta	UBERON:0001496	68.66	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.23	gold quality
Ammon’s horn	UBERON:0001954	66.89	gold quality
left adrenal gland	UBERON:0001234	66.86	gold quality
lower esophagus	UBERON:0013473	66.40	gold quality
omental fat pad	UBERON:0010414	66.29	gold quality
minor salivary gland	UBERON:0001830	65.99	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.66	gold quality
body of stomach	UBERON:0001161	65.39	gold quality
left ovary	UBERON:0002119	65.21	gold quality
spleen	UBERON:0002106	64.50	gold quality
right frontal lobe	UBERON:0002810	64.45	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.45	gold quality
cerebellar hemisphere	UBERON:0002245	64.40	gold quality
skin of leg	UBERON:0001511	64.35	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.34	gold quality
left adrenal gland cortex	UBERON:0035825	63.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ID1

Literature-anchored findings (GeneRIF, showing 40)

• A small regulatory microRNA, hsa-miR-381, has a major role in glioma progression. (PMID:21435336)
• Downregulation of miR-381 is associated with metastatic potential of lung adenocarcinoma. (PMID:22592211)
• miR-381 increases sensitivity of 786-O cells to 5-FU by inhibitory WEE1 and increase of Cdc2 activity in renal cancer cells. (PMID:23816136)
• Mir-381, mapped to the 14q32.31 locus, regulates proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. (PMID:24166498)
• Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance. (PMID:24303078)
• Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4. (PMID:24404152)
• The miR-381-NEFL axis is important for temozolomide resistance in glioblastoma multiforme. (PMID:25605243)
• miR-381 was induced in vitro by IL-1beta in ATDC5 cells, PMCs, and PHCs, and was expressed in areas of cartilage degradation or absorption in vivo (PMID:26184031)
• Report feedback loop between PTTG1 targeting miRNAs,including mir381, PTTG1 and p53 that promotes pituitary tumorigenesis. (PMID:26320179)
• Down-regulation of MicroRNA-381 promotes cell proliferation and invasion in colon cancer cells through up-regulation of LRH-1. (PMID:26320367)
• we are the first to identify that miR-381 suppresses C/EBPalpha-dependent Cx43 expression in breast cancer cells. The miR-381-C/EBPalpha-Cx43 axis might be a useful diagnostic and therapeutic target of metastatic breast cancer (PMID:26450928)
• The present study indicates that miR-381 may be a novel tumor suppressor that blocks HCC growth and invasion by targeting LRH-1. (PMID:26677080)
• miR-381 increased the activity of NF-kappaB signaling, thereby increasing the expression of IL-6, TNFalpha, and COX-2. (PMID:26688820)
• Knockdown of miR-381 target gene, YY1, mimicked the phenotype induced by miR-381 overexpression. (PMID:26768613)
• Our results suggest a general role of miR-206,-381, and 671-5p in SMARCB1 gene silencing of epithelioid sarcomas(ES) , extraskeletal myxoid chondrosarcomas , malignant peripheral nerve sheath tumors and synovial sarcomas . In the future, miR-765 could possibly be a diagnostic tool for ES because of its 97% specificity and 80% sensitivity. (PMID:27223121)
• bFGF inhibited microRNA-381 expression via the PDGFR and c-Src cascade. (PMID:27229532)
• these results demonstrated the mechanism that suppression of CD1c by BCG infection is mediated by miR-381-3p (PMID:27296666)
• enhanced miR-381a-3p expression contributed to the injury of osteoarthritis mainly by inhibiting the expression of IkappaBalpha. (PMID:27312547)
• Results show a strong negative correlation between the expression of miR-381 and LRRC4 in osteosarcoma (OS) tissues, indicating LRRC4 as a direct target gene of miR-381. (PMID:27612424)
• MiR-381 was predicted as a regulatory miRNA of CXCR4 in breast cancer. (PMID:28012397)
• Results show that MiR-381 was significantly down-regulated in gastric cancer tissues and cell lines. It may function as a tumor suppressor by directly targeting TMEM16A and regulating TGF-beta pathway and epithelial-mesenchymal transition process in the development of progression of gastric cancer. (PMID:28193228)
• Results found that MicroRNA-381 expression was decreased in osteosarcoma patients and correlated with advanced stages. MicroRNA-381 suppressed the proliferation and induced apoptosis of osteosarcoma cells through LRH-1/Wnt/beta-catenin signaling pathway. Besides, microRNA-381 may be an independent diagnostic and prognostic marker for osteosarcoma. (PMID:29207112)
• MicroRNA-381 inhibits cell proliferation and invasion in endometrial carcinoma by targeting the IGF-1R. (PMID:29257334)
• Restoration of miR-381 represents a potential therapeutic strategy for NSCLC. (PMID:29287202)
• Study demonstrated that UBE2C was over-expressed in rectal carcinoma, which was subjected to miR-381 modulation and in turn promoted cell proliferation, invasion and inhibited cell apoptosis. (PMID:29303411)
• miR-381-3p inhibition enhanced intestinal epithelial proliferation and barrier function and also attenuated remote organ injury and improved survival. (PMID:29540663)
• Study demonstrated that serum HMGB1 was upregulated and the expression levels of miR-381 were downregulated in patients with polymyositis (PM). Furthermore, high HMGB1 expression was associated with poor survival rate in patients with PM. A luciferase activity assay was used to confirm the binding of miR-381 and HMGB1 3’ untranslated region. (PMID:29956737)
• inhibition of CCNA2 mediated by miR-381-3p as the crucial biregulator not only participates in the proliferation regulation with CDK6 in cell cycle but also modulates the EMT progression via ROCK/AKT/beta-catenin/SNAIL pathway, which establishes an EMT circuit combined with miR-381-3p/MET/AKT/GSK-3beta/SNAIL pathway, and SNAIL is the last confocal target to induce EMT progression (PMID:30138038)
• MiR-381-3p was lowly expressed while FGF7 was highly expressed in cervical cancer cells. This study validated a direct target relationship and a negative correlation between miR-381-3p and FGF7. MiR-381-3p inhibited cell proliferation and metastasis, retarded cell cycle, and accelerated apoptosis in cervical cancer. (PMID:30161290)
• miR-381 induces sensitivity of breast cancer cells to doxorubicin by inactivation of MAPK signaling via FYN (PMID:30266665)
• ong noncoding RNA DLEU1 aggravates pancreatic ductal adenocarcinoma carcinogenesis via the miR-381/CXCR4 (PMID:30382579)
• miR-381 could overcome cisplatin resistance of breast cancer by directly targeting MDR1. (PMID:30444043)
• Taken together, the findings of this study suggest that the miR381/miR489mediated expression of CUL4B modulates the proliferation and invasion of GC cells via the Wnt/betacatenin pathway, which indicates that the miR381/miR489CUL4B axis is critical in the control of GC tumourigenesis. (PMID:30483755)
• Levels of miR381 were decreased in clear cell and endometrioid carcinoma ovarian cancer. Experimentally induced upregulation of miR381 led to a decrease in the level of PIK3CA in ovarian cancer cells and inhibition of ovarian cancer cells proliferation and migration. (PMID:30542723)
• Results found the expression of miR-381 in the severe periodontitis group was significantly higher than that of the no/mild periodontitis group with significant correlation and the mean probing pocket depth. Salivary hsa-miR-381-3p was correlated with periodontitis condition in chronic periodontitis patients. (PMID:30875931)
• miR-381 levels were significantly downregulated in renal cancer tissues and miR-381 inhibition promoted tumor cell growth, migration, and chemoresistance. (PMID:31299041)
• miRNA381, which was down-regulated in gastric cancer (GC), might be a novel early diagnosis marker for patients with GC. (PMID:31347326)
• Long non-coding RNA (lncRNA) small nucleolar RNA host gene 7 (SNHG7) promotes breast cancer progression by sponging miRNA-381. (PMID:31378900)
• the present study demonstrated that miR381 is downregulated in GC cells, and that miR381 may inhibit GC cell growth. Therefore, miR381 may serve as a novel target for the clinical treatment of GC in the future. (PMID:31545430)
• MicroRNA-381 inhibits lung adenocarcinoma cell biological progression by directly targeting LMO3 through regulation of the PI3K/Akt signaling pathway and epithelial-to-mesenchymal transition. (PMID:31646571)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir381	ENSMUSG00000098838

Paralogs (16): MIR494 (ENSG00000194717), MIR377 (ENSG00000199015), MIR369 (ENSG00000199025), MIR323A (ENSG00000199069), MIR410 (ENSG00000199092), MIR409 (ENSG00000199107), MIR539 (ENSG00000202560), MIR487A (ENSG00000207742), MIR487B (ENSG00000207754), MIR656 (ENSG00000207959), MIR496 (ENSG00000207961), MIR154 (ENSG00000207978), MIR323B (ENSG00000208004), MIR1185-1 (ENSG00000221525), MIR1185-2 (ENSG00000221614), MIR382 (ENSG00000283170)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.