MIR382

Summary

MIR382 (microRNA 382, HGNC:31875) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 494331 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31875
Approved symbol	MIR382
Name	microRNA 382
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-382
Ensembl gene	ENSG00000283170
Ensembl biotype	miRNA
Entrez	494331
RNAcentral	URS000075ABA3 — miRNA, 76 nt, 36 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637119

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637119 — 1 exons

Exon	Start	End
ENSE00003795687	101054306	101054381

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 96.37.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	96.37	gold quality
kidney	UBERON:0002113	93.10	gold quality
lung	UBERON:0002048	84.05	gold quality
stomach	UBERON:0000945	83.94	gold quality
placenta	UBERON:0001987	82.23	gold quality
intestine	UBERON:0000160	81.85	gold quality
heart	UBERON:0000948	80.80	gold quality
myometrium	UBERON:0001296	79.52	gold quality
colon	UBERON:0001155	76.58	gold quality
heart left ventricle	UBERON:0002084	75.79	gold quality
left adrenal gland cortex	UBERON:0035825	75.31	gold quality
blood	UBERON:0000178	74.10	gold quality
islet of Langerhans	UBERON:0000006	73.22	gold quality
left adrenal gland	UBERON:0001234	71.74	gold quality
calcaneal tendon	UBERON:0003701	70.65	gold quality
transverse colon	UBERON:0001157	69.81	gold quality
right frontal lobe	UBERON:0002810	69.48	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.20	gold quality
substantia nigra	UBERON:0002038	68.33	gold quality
left ovary	UBERON:0002119	67.54	gold quality
adipose tissue	UBERON:0001013	67.53	gold quality
prostate gland	UBERON:0002367	67.14	gold quality
omental fat pad	UBERON:0010414	67.12	gold quality
putamen	UBERON:0001874	66.07	gold quality
Ammon’s horn	UBERON:0001954	65.68	gold quality
body of pancreas	UBERON:0001150	64.84	gold quality
body of stomach	UBERON:0001161	64.80	gold quality
thoracic mammary gland	UBERON:0005200	64.53	gold quality
skin of abdomen	UBERON:0001416	64.15	gold quality
caudate nucleus	UBERON:0001873	64.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• The study provided evidence in the form of reciprocal expression at the protein level for a large number of predicted miRNA-target pairs and discovered a novel role of miR-382 in the loss of epithelial characteristics induced by TGFbeta1. (PMID:20716515)
• MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients. (PMID:23542694)
• Hsa-mir-93, hsa-mir-17, hsa-mir-22*, hsa-mir-126*, hsa-mir-142-3p, hsa-mir-144*, hsa-mir-486-5p, hsa-mir-451, and hsa-mir-92a were up-regulated and hsa-mir-30a, hsa-mir-382, and hsa-mir-136 were down-regulated in bromocriptine-resistant prolactinomas (PMID:25064468)
• RP5-833A20.1/miR-382-5p/NFIA pathway was essential to the regulation of cholesterol homeostasis and inflammatory reactions. (PMID:25265644)
• miR-382 inhibits osteosarcoma metastasis and relapse by targeting YB-1 protein. (PMID:25292190)
• miR-382 is a tumor suppressor miRNA and induction of miR-382 is a potential strategy to inhibit osteosarcoma progression. (PMID:25344865)
• Inhibition of miR-382 in a weakly tumorigenic melanoma cell line increased tumor progression and metastasis in vivo. (PMID:25677173)
• miR-382 levels are reverse-correlated with esophageal squamous cell carcinoma poor outcomes, suggesting that miR-382 could be a potential predictive biomarker for both prognosis and treatment of ESCC. (PMID:26078564)
• these findings revealed that miR382 inhibits migration and invision by targeting ROR1 through regulating EMT in ovarian cancer, and might serve as a tumor suppressor in ovarian cancer. (PMID:26575700)
• Identify miR-382 as a promoter for hepatocyte proliferation and cell growth via targeting PTEN-Akt axis. (PMID:26636539)
• MiR-382 is significantly downregulated in colorectal cancer tissues and cell lines. (PMID:26800338)
• long term non progressors (LTNPs) have substantial lower expression of miR-382-5p that positively correlates with viral loads. Combinatorial regulation is highly probable in dictating differential disease progression as average expression of miR-382-5p and miR-155-5p can substantially distinguish LTNP individuals from regular progressors. (PMID:27320691)
• the miR-382-5p/MXD1 axis plays a critical role in myelopoiesis by affecting the lineage choice of CD34(+) hematopoietic stem/progenitor cells. (PMID:27520398)
• this study shows that miR-382-5p expression is negatively correlated with RERG expression, and functions as an independent oncomiR for the higher incidence and poorer prognosis of breast cancer (PMID:27705918)
• miR-382 inhibits prostate cancer cell proliferation and metastasis through inhibiting COUPTFII. (PMID:27748848)
• Circulating miRNA-221-3p and miRNA-382-5p might be used as potential noninvasive biomarkers for the diagnosis of ischemic stroke. (PMID:28111007)
• Clinical data showed that upregulation of miR-382/3-NT and downregulation of HSPD1/Trx were also observed in IgA nephropathy patients with renal interstitial fibrosis. These data supported a novel mechanism in which miR-382 targets HSPD1 and contributes to the redox imbalance in the development of renal fibrosis. (PMID:28680529)
• miR-382 functions as a tumor suppressor against esophageal squamous cell carcinoma development and metastasis (PMID:28694664)
• Overexpression of miR-382 led to a significant downregulation of EZH2 while knockdown of miR-382 significantly increased the level of EZH2 both in mRNA and protein levels. (PMID:28813705)
• Overexpression of MMP2 and MMP16 in endometrial cancerous tissues corresponded to down-regulation of miR-377, miR-382 and miR-410, while decreased expression of TIMP2 was associated with miR-200b up-regulation. (PMID:28871006)
• MicroRNA-382 inhibits cell proliferation and invasion of retinoblastoma by targeting BDNF-mediated PI3K/AKT signaling pathway. (PMID:28901408)
• that oncogenic SETD8 was regulated by miR-382 and involved glioma progression (PMID:29487005)
• MiR-382 functions as tumor suppressor and chemosensitizer in colorectal cancer. (PMID:29700213)
• NEAT1 promoted ovarian cancer cells metastasis through regulating the miR-382-3p/ROCK1 axis (PMID:29790629)
• silencing of miR-382-5p induces a mitonuclear protein imbalance and activates the mtUPR in skeletal muscle (PMID:30417335)
• study highlights the miR-382-5p/PTEN (phosphatase and tensin homolog protein) axis as an important factor in ATRA-induced granulocytic differentiation in acute promyelocytic leukemia. (PMID:30453015)
• the present study describes a potential mechanism underlying a MIR-382/SP1 link contributing to colorectal cancer development. Thus, MIR-382 may be able to be developed as a novel treatment target for colorectal cancer. (PMID:30474556)
• Insertion/deletion polymorphism in the 3’ untranslated region of COL1A2 disrupts its interaction with microRNA-382 and leads to decreased susceptibility to osteoporotic fracture. (PMID:30825231)
• miR-382-3p participated in osteoarthritis maybe through the TLR4/MyD88/NF-kappaB signaling pathway by directly targeting CX43. (PMID:31144313)
• Authors revealed that miR3825p was overexpressed in CAFs compared with that in fibroblasts of adjacent normal tissue and miR3825p overexpression was responsible for OSCC cell migration and invasion. (PMID:31364748)
• Low miR382 expression is associated with non-small cell lung cancer. (PMID:31479715)
• Compared with noncancerous breast tissues, miRNA-382-5p expression was upregulated but MXD1 mRNA expression was downregulated in breast cancer tissues. The dysregulation of miRNA-382-5p-MXD1 axis may be involved in the development and aggressive progression of breast cancer. miRNA-382-5p may target MXD1, leading to cell invasion and proliferation in breast cancer cells in vitro. (PMID:31635836)
• Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs. (PMID:31747371)
• CircAP2A2 acts as a ceRNA to participate in infantile hemangiomas progression by sponging miR-382-5p via regulating the expression of VEGFA. (PMID:32091151)
• Circ_0001178 regulates miR-382/VEGFA axis to facilitate hepatocellular carcinoma progression. (PMID:32240747)
• Circular RNA hsa_circ_0008285 inhibits colorectal cancer cell proliferation and migration via the miR-382-5p/PTEN axis. (PMID:32423803)
• microRNA-382 suppresses the progression of pancreatic cancer through the PI3K/Akt signaling pathway by inhibition of Anxa3. (PMID:32463333)
• circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis. (PMID:32690086)
• [Overexpression of miR-382-5p Mediated Downregulation of PTEN on Malignant Biological Behavior of Human Glioma U251 Cells]. (PMID:32975076)
• Circular RNA circ_0000467 regulates colorectal cancer development via miR-382-5p/EN2 axis. (PMID:33685351)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir382	ENSMUSG00000065428

Paralogs (16): MIR494 (ENSG00000194717), MIR377 (ENSG00000199015), MIR381 (ENSG00000199020), MIR369 (ENSG00000199025), MIR323A (ENSG00000199069), MIR410 (ENSG00000199092), MIR409 (ENSG00000199107), MIR539 (ENSG00000202560), MIR487A (ENSG00000207742), MIR487B (ENSG00000207754), MIR656 (ENSG00000207959), MIR496 (ENSG00000207961), MIR154 (ENSG00000207978), MIR323B (ENSG00000208004), MIR1185-1 (ENSG00000221525), MIR1185-2 (ENSG00000221614)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.