MIR383

Summary

MIR383 (microRNA 383, HGNC:31876) is a microRNA gene on chromosome 8p22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 494332 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31876
Approved symbol	MIR383
Name	microRNA 383
Location	8p22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-383
Ensembl gene	ENSG00000199127
Ensembl biotype	miRNA
Entrez	494332
RNAcentral	URS00004A6370 — miRNA, 73 nt, 39 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362257

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362257 — 1 exons

Exon	Start	End
ENSE00001437020	14853438	14853510

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 79.83.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	79.83	gold quality
adrenal tissue	UBERON:0018303	76.06	gold quality
blood	UBERON:0000178	75.21	gold quality
intestine	UBERON:0000160	74.66	gold quality
stomach	UBERON:0000945	74.35	gold quality
body of pancreas	UBERON:0001150	69.22	gold quality
left adrenal gland	UBERON:0001234	67.85	gold quality
vagina	UBERON:0000996	66.23	gold quality
ascending aorta	UBERON:0001496	66.03	gold quality
heart left ventricle	UBERON:0002084	65.78	gold quality
esophagus mucosa	UBERON:0002469	64.43	gold quality
left ovary	UBERON:0002119	63.95	gold quality
ovary	UBERON:0000992	63.94	gold quality
cerebellar hemisphere	UBERON:0002245	62.33	gold quality
corpus callosum	UBERON:0002336	61.29	gold quality
skin of leg	UBERON:0001511	61.08	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.05	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.68	gold quality
lung	UBERON:0002048	60.14	gold quality
nucleus accumbens	UBERON:0001882	58.69	gold quality
left testis	UBERON:0004533	57.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• The miR-383 functions as a negative regulator of proliferation by targeting IRF1. (PMID:21368870)
• Expression of hsa-miR-373 is down-regulated by aberrant methylation in colon cancer and that this miRNA may function by regulating expression of the oncogene RAB22A. (PMID:21785829)
• Medulloblastoma tumors exhibit decreased expression of miR-383 but elevated expression of PRDX3. Up-regulation of miR-383 knocks down the expression of PRDX3, inhibits cell proliferation and promotes apoptosis. (PMID:23157748)
• This study demonistrated that miR-383 acts as a regulator controlling cell growth of medulloblastoma, at least in part, through targeting PRDX3. (PMID:23227829)
• We report that miR-383 was downregulated in gliomas and inversely correlated with glioma pathological grades; we demonstrated that IGF1R expression is critical for miR-383 downregulation-induced cell invasion. (PMID:23564324)
• The miR-383 decreases the levels and focal formation of gammaH2AX under treatment with UV and cisplatin by targeting PNUTS directly and inducing cell cycle arrest at the G1 phase. (PMID:24462707)
• demonstrate for the first time that miR-383 can specifically regulates the expression of Gadd45g by directly targeting to the 3-UTR region of Gadd45g mRNA, a regulatory process conserved in human tumor cells and mouse embryonic stem cells (PMID:25415264)
• In summary, this study suggested that miR-383 plays the role of tumor suppressor by targeting CCND1 in glioma cells, and may be useful for developing a new therapeutic strategy for gliomas. (PMID:25450356)
• Loss of MIR383 expression is associated with glioma. (PMID:25936342)
• ATR is down-regulated by STAT3-regulated microRNA-383 in A431 cells. (PMID:26261078)
• Recombinant human APRIL (rhAPRIL) could rescue HCC cell proliferation inhibited by miR-383. (PMID:26385772)
• Data suggest 5S ribosomal RNA is a direct target of miR-150 and miR-383 in esophageal squamous cell carcinoma (ESCC); overexpression of miR-150 and miR-383 inhibits ESCC cell proliferation in vitro and in vivo and intensifies RPL11/c-Myc interaction. (PMID:26606907)
• Endogenous miR-383 is a functional tumor suppressor in non-small cell lung cancer. (PMID:27551765)
• Inhibition of miR-383 has profound tumor suppressing effect on epithelial ovarian cancer. (PMID:27567588)
• miR-383 inhibits proliferation, migration and angiogenesis of glioma-exposed endothelial cells in vitro via VEGF/VEGFR2-mediated FAK and Src signaling pathways. (PMID:27693218)
• MicroRNA-383 is a tumor suppressor in human lung cancer by inhibiting EPAS1, both of which could serve as potential therapeutic targets in the treatment of lung cancer. (PMID:27862077)
• Expression analyses of miR-383 in PCa clinical tissues established that low miR-383 expression is associated with poor prognosis. Functional data suggest that miR-383 regulates PCa tumor-initiating/stem-like cells via CD44 regulation. Ectopic expression of miR-383 inhibited tumor-initiating capacity of CD44+ PCa cells (PMID:27893706)
• miR-383 regulated lactate dehydrogenase expression in ovarian cancer cells, thereby stunting glycolysis, cell proliferation and invasion (PMID:28043152)
• Low miR383 expression is associated with Intestinal-Type Gastric Cancer. (PMID:28243881)
• Suppression of miR-383 may increase the therapeutic potential of human bone-marrow-derived MSCs in treating spinal cord injury via augmentation of GDNF protein levels. (PMID:28365701)
• Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1-ETO/THAP10/miR-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 predicts a poor clinical outcome and represents a novel therapeutic target. (PMID:28539478)
• Suppression of miR-383 in Human Bone-Marrow-Derived Mesenchymal Stem Cells not only upregulated GDNF protein, but also increased vascular endothelial growth factor A (VEGF-A) and cyclin-dependent kinase 19 (CDK19), two other miR-383 targets. (PMID:29763918)
• Data show that miR-383 targeted the 3’ untranslated regions (3’-UTR) of CREPT mRNA directly. (PMID:29938829)
• AKR1B10 modulated regulated by miR-383-5p, promotes hepatocellular carcinoma tumor progress. (PMID:30038373)
• MiR-383 serves as a tumor-suppressor in the cholangiocarcinoma.MiR-383 regulates cholangiocarcinoma cell proliferation, migration, and invasion via directly targeting IRF1.High expression of miR-383 was correlated with advanced tumor stage, large tumor size, present vascular invasion, and metastasis in the cholangiocarcinoma. (PMID:30145803)
• Up-regulation of miR-383-5p inhibited cell proliferation, tumor growth and enhanced chemosensitivity of ovarian cancer cells through suppressing TRIM27 expression. (PMID:30399596)
• that HOXC13-AS exerted oncogenic function in nasopharyngeal carcinoma via regulating miR-383-3p/HMGA2 axis (PMID:30536950)
• MicroRNA-383 inhibits doxorubicin resistance in hepatocellular carcinoma by targeting eukaryotic translation initiation factor 5A2. (PMID:30801960)
• association of KCTD12 gene and miR-383-binding genes with rumination (PMID:30886212)
• MiR-383 was significantly down-regulated in gastric cancer tissues.Cyclin E2 was a target of miR-383 in gastric cancer cells. (PMID:31170011)
• Study found that PTTG3P was up-regulated in hepatocellular carcinoma (HCC) tissues and cells. Functional experiments demonstrated that knockdown of PTTG3P inhibited cell proliferation, migration and invasion, and promoted cell apoptosis, acting as an oncogene. Mechanistically, PTTG3P upregulated the expression of miR-383 targets CCND1 and PARP2 by sponging miR-383, acting as a competing endogenous RNA. (PMID:31340767)
• RP11-284F21.9 knockdown could reduce MAL2 expression, while miR-383-5p inhibitors abolished this repressive effect (PMID:31397491)
• miR-383 may play a anti-tumor role in the pathogenesis of hepatocellular carcinoma by targeting IL-17 through STAT3 signaling pathway. (PMID:31648164)
• miR-383-5p exhibits conspicuous low expression in cervical cancer (CC) tissues. miR-383-5p binds to stratifin (SFN) and has anti-cancerous effects in CC. Long intergenic non-protein coding RNA 1128 expedites cellular process in CC by binding with miR-383-5p to release SFN. (PMID:31779593)
• MicroRNA-383 suppresses pancreatic carcinoma development via inhibition of GAB1 expression. (PMID:31858540)
• MicroRNA-383-5p acts as a potential prognostic biomarker and an inhibitor of tumor cell proliferation, migration, and invasion in breast cancer. (PMID:31903982)
• LncRNA LUADT1 inhibits cell apoptosis in diabetic retinopathy by regulating miR-383/peroxiredoxin 3 axis. (PMID:32125187)
• MicroRNA-383 inhibits proliferation, migration, and invasion in hepatocellular carcinoma cells by targeting PHF8. (PMID:32441881)
• Expression and clinical diagnostic value of miR-383 in patients with severe preeclampsia. (PMID:32538753)
• LINC00162 participates in the pathogenesis of diabetic nephropathy via modulating the miR-383/HDAC9 signalling pathway. (PMID:32677473)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Mir383	ENSRNOG00000035589

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.