MIR384

Summary

MIR384 (microRNA 384, HGNC:31878) is a microRNA gene on chromosome Xq21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 494333 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31878
Approved symbol	MIR384
Name	microRNA 384
Location	Xq21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-384
Ensembl gene	ENSG00000283242
Ensembl biotype	miRNA
Entrez	494333
RNAcentral	URS000070E91B — miRNA, 88 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000638003

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000638003 — 1 exons

Exon	Start	End
ENSE00003797532	76919273	76919360

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 79.68.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	79.68	gold quality
lung	UBERON:0002048	75.31	gold quality
kidney	UBERON:0002113	74.48	gold quality
Ammon’s horn	UBERON:0001954	68.85	gold quality
blood	UBERON:0000178	68.80	gold quality
amygdala	UBERON:0001876	67.99	gold quality
corpus callosum	UBERON:0002336	67.69	gold quality
liver	UBERON:0002107	66.21	silver quality
tibial nerve	UBERON:0001323	64.71	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.78	gold quality
caudate nucleus	UBERON:0001873	60.49	gold quality
skin of abdomen	UBERON:0001416	60.29	gold quality
intestine	UBERON:0000160	60.07	gold quality
hypothalamus	UBERON:0001898	59.58	gold quality
right frontal lobe	UBERON:0002810	55.56	gold quality
thyroid gland	UBERON:0002046	54.72	gold quality
cerebellar hemisphere	UBERON:0002245	54.18	gold quality
left testis	UBERON:0004533	50.95	gold quality
colon	UBERON:0001155	47.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 37)

• MicroRNA-384 regulates both amyloid precursor protein and BACE-1 expression. (PMID:24827165)
• Taken together, our results suggest that miR-384-5p mediated ER stress by negatively regulating GRP78 and that miR-384-5p inhibition might be a novel and promising approach for the treatment of PD. (PMID:26864693)
• Low MIR384 expression is associated with hepatocellular carcinoma. (PMID:27542674)
• this study shows that miR-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42 (PMID:27769041)
• Pleiotrophin, a target of miR-384, promotes proliferation, metastasis and lipogenesis in hepatitis B virus-related hepatocellular carcinoma. (PMID:28557334)
• Low miR384 expression is associated with renal cell carcinoma. (PMID:28877780)
• miR-384 and AEG-1 may serve as potential targets for the diagnosis and treatment of non-small-cell lung cancer. (PMID:28938524)
• Up-regulation of miR-384 significantly inhibited the proliferation, migration, and invasion of osteosarcoma cells in vitro by directly targeting SETD8, but down-regulation of miR-384 by mimics had the opposite effects. (PMID:29630102)
• Study confirmed that miR-384 is downregulated in breast cancer, especially in triple-negative breast cancer. Meanwhile, miR-384 functions as a tumor suppressor in breast cancer by targeting ACVR1 and impacting ACVR1/Wnt signaling. (PMID:29693185)
• MiR-384 repressed tumorigenesis by regulating CDK6 in ccRCC and predicted good prognosis for ccRCC. (PMID:30003753)
• Multipoint targeting of TGF-beta/Wnt transactivation circuit with microRNA 384-5p for cardiac fibrosis. (PMID:30206318)
• The Core-Notch network is constructed to screen microRNAs implicated in inner ear development, and miRNA-384-5p is screened and verified to be target-regulating the Notch signaling pathway, which could be the potential target in the regeneration of impaired hair cells. (PMID:30453402)
• Results show that miR-384 expression is markedly downregulated in laryngeal cancer (LC) tissue and cell lines, and indicate that miR-384 regulates LC cell proliferation and apoptosis through targeting WISP1. (PMID:30548664)
• Up-regulation of MIRN384 inhibits the progression of esophageal squamous cell carcinoma by suppressing LIMK1/cofilin signaling. (PMID:30551528)
• These findings suggested that there was a negative correlation between long non-coding RNA TUG1 and miR-384 in nasopharyngeal carcinoma patients. (PMID:30581000)
• AFAP1-AS1 functions as an endogenous RNA by competitively binding to miR-384 to regulate ACVR1, thus conferring inhibitory effects on pancreatic cancer cell stemness and tumorigenicity (PMID:30819221)
• Knocking down miR-384 promotes growth and metastasis of osteosarcoma MG63 cells by targeting SLBP (PMID:31007083)
• Knockdown of SNHG3 upregulated miR-384 expression and that overexpression of miR-384 decreased SNHG3. Inhibition of miR-384 markedly increased WEE1 expression. (PMID:31238052)
• Down-regulated circPAPPA suppresses the proliferation and invasion of trophoblast cells via the miR-384/STAT3 pathway. (PMID:31427481)
• ANRIL is involved in hepatocellular carcinoma progression by direct targeting of miR-384 and STAT3. (PMID:31679275)
• interference of miR-212 and miR-384 alleviated osteoporosis (OP) via RUNX2/OPG/RANKL pathway, providing a novel target of treating OP. (PMID:31891679)
• miRNA3845p regulates the progression of Parkinson’s disease by targeting SIRT1 in mice and SHSY5Y cell. (PMID:31894288)
• Circular RNA hsa_circ_0006168 contributes to cell proliferation, migration and invasion in esophageal cancer by regulating miR-384/RBBP7 axis via activation of S6K/S6 pathway. (PMID:31957828)
• MicroRNA-384 Inhibits the Progression of Papillary Thyroid Cancer by Targeting PRKACB. (PMID:31998791)
• MiR-384 Inhibits Malignant Biological Behavior Such as Proliferation and Invasion of Osteosarcoma by Regulating IGFBP3. (PMID:32129151)
• LncRNA MALAT1 knockdown inhibits cell migration and invasion by suppressing autophagy through miR-384/GOLM1 axis in glioma. (PMID:32196610)
• Circular RNA circCNOT6L regulates cell development through modulating miR-384/FN1 axis in esophageal squamous cell carcinoma. (PMID:32329843)
• MiR-384 inhibits proliferation and migration of trophoblast cells via targeting PTBP3. (PMID:32512528)
• CircBPTF knockdown ameliorates high glucose-induced inflammatory injuries and oxidative stress by targeting the miR-384/LIN28B axis in human umbilical vein endothelial cells. (PMID:32524321)
• Circular RNA-hsa-circ-0000670 promotes gastric cancer progression through the microRNA-384/SIX4 axis. (PMID:32535033)
• Deregulated miR-384 serves as a biomarker in neonatal hypoxic-ischemic encephalopathy and alleviates microglia-mediated neuroinflammation. (PMID:32621118)
• Circ_0000376 enhances the proliferation, metastasis, and chemoresistance of NSCLC cells via repressing miR-384. (PMID:32716343)
• Circ_0037866 Contributes to the Tumorigenesis of Renal Cell Carcinoma by Sequestering miR-384 to Elevate Chromobox 5 Expression. (PMID:35249038)
• MiRNA-384-5p Targets GABRB1 to Regulate Ketamine-Induced Neurotoxicity in Neurons. (PMID:35416273)
• MicroRNA-384-5p protects against cardiac hypertrophy via the ALPK3 signaling pathway. (PMID:35510648)
• Circ_0008285 knockdown represses tumor development by miR-384/RRM2 axis in hepatocellular carcinoma. (PMID:35964907)
• Silencing LINC00491 inhibits prostate cancer development through the miR-384/TRIM44 axis. (PMID:37070216)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.