MIR3907

Summary

MIR3907 (microRNA 3907, HGNC:38988) is a microRNA gene on chromosome 7q36.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500835 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38988
Approved symbol	MIR3907
Name	microRNA 3907
Location	7q36.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3907
Ensembl gene	ENSG00000265810
Ensembl biotype	miRNA
Entrez	100500835
RNAcentral	URS0000759E9D — miRNA, 151 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579424

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579424 — 1 exons

Exon	Start	End
ENSE00002706925	151433489	151433639

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 84.59.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of thyroid gland	UBERON:0001119	84.59	gold quality
thyroid gland	UBERON:0002046	81.89	gold quality
left lobe of thyroid gland	UBERON:0001120	81.30	gold quality
prefrontal cortex	UBERON:0000451	77.49	gold quality
monocyte	CL:0000576	73.74	gold quality
blood	UBERON:0000178	73.20	gold quality
myometrium	UBERON:0001296	72.23	gold quality
adult mammalian kidney	UBERON:0000082	70.22	gold quality
endocervix	UBERON:0000458	70.10	gold quality
gastrocnemius	UBERON:0001388	69.03	gold quality
urinary bladder	UBERON:0001255	68.00	gold quality
islet of Langerhans	UBERON:0000006	67.20	gold quality
body of stomach	UBERON:0001161	66.10	gold quality
tibial artery	UBERON:0007610	65.89	gold quality
ascending aorta	UBERON:0001496	65.73	gold quality
thoracic aorta	UBERON:0001515	65.71	gold quality
kidney	UBERON:0002113	65.10	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.91	gold quality
body of pancreas	UBERON:0001150	64.83	gold quality
heart left ventricle	UBERON:0002084	64.66	gold quality
thoracic mammary gland	UBERON:0005200	64.59	gold quality
right ovary	UBERON:0002118	64.06	gold quality
omental fat pad	UBERON:0010414	63.84	gold quality
endometrium	UBERON:0001295	63.67	gold quality
adipose tissue	UBERON:0001013	63.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.61	gold quality
left coronary artery	UBERON:0001626	63.56	gold quality
stomach	UBERON:0000945	63.55	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.38	gold quality
left ovary	UBERON:0002119	63.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• [Screening of differently expressed miRNAs and the mechanism of miR-3907 in meibomian gland carcinoma]. (PMID:35280029)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.