MIR3908

Summary

MIR3908 (microRNA 3908, HGNC:38991) is a microRNA gene on chromosome 12q24.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500909 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38991
Approved symbol	MIR3908
Name	microRNA 3908
Location	12q24.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3908
Ensembl gene	ENSG00000266655
Ensembl biotype	miRNA
Entrez	100500909
RNAcentral	URS000075C62E — miRNA, 126 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579798

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579798 — 1 exons

Exon	Start	End
ENSE00002715241	123536409	123536534

Expression profiles

Bgee: expression breadth broad, 81 present calls, max score 83.19.

Top tissues by expression

81 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
superior frontal gyrus	UBERON:0002661	83.19	gold quality
adult mammalian kidney	UBERON:0000082	76.97	gold quality
blood	UBERON:0000178	75.91	gold quality
monocyte	CL:0000576	75.24	gold quality
islet of Langerhans	UBERON:0000006	72.62	gold quality
stomach	UBERON:0000945	70.91	gold quality
gastrocnemius	UBERON:0001388	70.43	gold quality
bone marrow	UBERON:0002371	69.88	gold quality
body of pancreas	UBERON:0001150	69.44	gold quality
liver	UBERON:0002107	69.19	gold quality
endometrium	UBERON:0001295	69.18	gold quality
body of stomach	UBERON:0001161	68.36	gold quality
descending thoracic aorta	UBERON:0002345	68.06	gold quality
ascending aorta	UBERON:0001496	67.56	gold quality
thoracic aorta	UBERON:0001515	67.22	gold quality
popliteal artery	UBERON:0002250	66.32	gold quality
tibial artery	UBERON:0007610	66.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.85	gold quality
Ammon’s horn	UBERON:0001954	65.52	gold quality
omental fat pad	UBERON:0010414	65.39	gold quality
esophagus mucosa	UBERON:0002469	64.94	gold quality
ectocervix	UBERON:0012249	64.77	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.60	gold quality
heart	UBERON:0000948	64.29	gold quality
body of uterus	UBERON:0009853	64.24	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.23	gold quality
amygdala	UBERON:0001876	64.05	gold quality
right atrium auricular region	UBERON:0006631	64.01	gold quality
intestine	UBERON:0000160	64.00	gold quality
colon	UBERON:0001155	63.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.38

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Low mir3908 expression is associated with breast cancer. (PMID:28327197)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.