MIR3909

Summary

MIR3909 (microRNA 3909, HGNC:38987) is a microRNA gene on chromosome 22q12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500826 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38987
Approved symbol	MIR3909
Name	microRNA 3909
Location	22q12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3909
Ensembl gene	ENSG00000266320
Ensembl biotype	miRNA
Entrez	100500826
RNAcentral	URS000075C219 — miRNA, 119 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579518

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579518 — 1 exons

Exon	Start	End
ENSE00002688574	35335640	35335758

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 88.46.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	88.46	gold quality
blood	UBERON:0000178	84.76	gold quality
monocyte	CL:0000576	82.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.49	gold quality
islet of Langerhans	UBERON:0000006	75.01	gold quality
skeletal muscle tissue	UBERON:0001134	74.88	gold quality
skin of abdomen	UBERON:0001416	74.72	gold quality
skin of leg	UBERON:0001511	74.71	gold quality
zone of skin	UBERON:0000014	74.67	gold quality
left uterine tube	UBERON:0001303	74.51	gold quality
esophagus mucosa	UBERON:0002469	74.34	gold quality
ectocervix	UBERON:0012249	73.92	gold quality
liver	UBERON:0002107	73.75	gold quality
muscle of leg	UBERON:0001383	73.71	gold quality
gastrocnemius	UBERON:0001388	73.21	gold quality
vagina	UBERON:0000996	73.15	gold quality
vermiform appendix	UBERON:0001154	73.00	gold quality
esophagus	UBERON:0001043	72.71	gold quality
fallopian tube	UBERON:0003889	72.50	gold quality
body of pancreas	UBERON:0001150	72.32	gold quality
right lobe of liver	UBERON:0001114	71.96	gold quality
multicellular organism	UBERON:0000468	71.76	gold quality
lung	UBERON:0002048	71.65	gold quality
stomach	UBERON:0000945	71.55	gold quality
upper lobe of left lung	UBERON:0008952	71.47	gold quality
body of stomach	UBERON:0001161	71.14	gold quality
left adrenal gland cortex	UBERON:0035825	70.12	gold quality
left coronary artery	UBERON:0001626	69.99	gold quality
heart left ventricle	UBERON:0002084	69.98	gold quality
saliva-secreting gland	UBERON:0001044	69.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.11

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.