MIR3910-1

Summary

MIR3910-1 (microRNA 3910-1, HGNC:38966) is a microRNA gene on chromosome 9q22.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500821 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38966
Approved symbol	MIR3910-1
Name	microRNA 3910-1
Location	9q22.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3910-1
Ensembl gene	ENSG00000266855
Ensembl biotype	miRNA
Entrez	100500821
RNAcentral	URS000075AEE1 — ncRNA, 111 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580936

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580936 — 1 exons

Exon	Start	End
ENSE00002695150	91636251	91636361

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 75.12.

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	75.12	gold quality
lung	UBERON:0002048	74.43	gold quality
esophagus mucosa	UBERON:0002469	70.75	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.60	gold quality
stomach	UBERON:0000945	69.53	gold quality
left adrenal gland cortex	UBERON:0035825	68.39	gold quality
intestine	UBERON:0000160	67.94	gold quality
omental fat pad	UBERON:0010414	67.87	gold quality
colon	UBERON:0001155	67.82	gold quality
body of stomach	UBERON:0001161	67.77	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.42	gold quality
hypothalamus	UBERON:0001898	67.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.08	gold quality
liver	UBERON:0002107	66.84	gold quality
transverse colon	UBERON:0001157	66.64	gold quality
endometrium	UBERON:0001295	66.32	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.96	gold quality
heart	UBERON:0000948	65.55	gold quality
body of uterus	UBERON:0009853	64.80	gold quality
myometrium	UBERON:0001296	64.74	gold quality
right frontal lobe	UBERON:0002810	64.42	gold quality
prostate gland	UBERON:0002367	63.51	gold quality
skin of leg	UBERON:0001511	63.44	gold quality
left ovary	UBERON:0002119	60.77	gold quality
right atrium auricular region	UBERON:0006631	60.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-3910 activated YAP signaling by targeting MST1, promoting the growth and migration of hepatocellular carcinomas. (PMID:28823082)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.