MIR3911

Summary

MIR3911 (microRNA 3911, HGNC:38962) is a microRNA gene on chromosome 9q34.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500872 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38962
Approved symbol	MIR3911
Name	microRNA 3911
Location	9q34.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3911
Ensembl gene	ENSG00000283874
Ensembl biotype	miRNA
Entrez	100500872
RNAcentral	URS000075C684 — miRNA, 109 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577791

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577791 — 1 exons

Exon	Start	End
ENSE00002692987	127690687	127690795

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 87.28.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	87.28	gold quality
subcutaneous adipose tissue	UBERON:0002190	81.29	gold quality
myometrium	UBERON:0001296	81.26	gold quality
adrenal gland	UBERON:0002369	80.18	gold quality
tibial nerve	UBERON:0001323	79.04	gold quality
kidney	UBERON:0002113	78.70	gold quality
lymph node	UBERON:0000029	76.51	gold quality
monocyte	CL:0000576	75.69	gold quality
lung	UBERON:0002048	74.47	gold quality
left ovary	UBERON:0002119	73.38	gold quality
islet of Langerhans	UBERON:0000006	72.15	gold quality
heart left ventricle	UBERON:0002084	71.99	gold quality
upper lobe of left lung	UBERON:0008952	71.41	gold quality
brain	UBERON:0000955	71.00	gold quality
spleen	UBERON:0002106	70.70	gold quality
blood	UBERON:0000178	70.67	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.43	gold quality
endometrium	UBERON:0001295	70.14	gold quality
pancreas	UBERON:0001264	69.56	gold quality
vermiform appendix	UBERON:0001154	69.18	gold quality
hypothalamus	UBERON:0001898	68.30	gold quality
caudate nucleus	UBERON:0001873	67.60	gold quality
left lobe of thyroid gland	UBERON:0001120	66.95	gold quality
stomach	UBERON:0000945	66.85	gold quality
muscle of leg	UBERON:0001383	66.69	gold quality
body of uterus	UBERON:0009853	66.59	gold quality
body of stomach	UBERON:0001161	66.55	gold quality
prostate gland	UBERON:0002367	66.37	gold quality
adipose tissue	UBERON:0001013	66.22	gold quality
multicellular organism	UBERON:0000468	66.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.