MIR3912

Summary

MIR3912 (microRNA 3912, HGNC:38923) is a microRNA gene on chromosome 5q35.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500831 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38923
Approved symbol	MIR3912
Name	microRNA 3912
Location	5q35.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3912
Ensembl gene	ENSG00000264249
Ensembl biotype	miRNA
Entrez	100500831
RNAcentral	URS0000759CA1 — miRNA, 105 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577566

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577566 — 1 exons

Exon	Start	End
ENSE00002699994	171386656	171386760

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 78.13.

Top tissues by expression

33 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	78.13	gold quality
monocyte	CL:0000576	75.36	gold quality
endometrium	UBERON:0001295	74.58	gold quality
right lobe of liver	UBERON:0001114	74.37	gold quality
gastrocnemius	UBERON:0001388	74.24	gold quality
esophagus mucosa	UBERON:0002469	72.47	gold quality
left adrenal gland cortex	UBERON:0035825	71.73	gold quality
omental fat pad	UBERON:0010414	69.92	gold quality
skin of abdomen	UBERON:0001416	69.58	gold quality
transverse colon	UBERON:0001157	69.28	gold quality
minor salivary gland	UBERON:0001830	68.92	gold quality
skin of leg	UBERON:0001511	68.91	gold quality
right ovary	UBERON:0002118	68.44	gold quality
adrenal tissue	UBERON:0018303	68.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.25	gold quality
pituitary gland	UBERON:0000007	67.81	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.59	gold quality
tibial artery	UBERON:0007610	67.37	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.28	gold quality
body of stomach	UBERON:0001161	66.68	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.31	gold quality
tibial nerve	UBERON:0001323	65.59	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.87	gold quality
spleen	UBERON:0002106	64.17	gold quality
cerebellar hemisphere	UBERON:0002245	63.80	gold quality
putamen	UBERON:0001874	62.60	gold quality
prostate gland	UBERON:0002367	60.63	gold quality
caudate nucleus	UBERON:0001873	58.48	gold quality
hypothalamus	UBERON:0001898	58.35	gold quality
right testis	UBERON:0004534	56.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.