MIR3913-1

Summary

MIR3913-1 (microRNA 3913-1, HGNC:38884) is a microRNA gene on chromosome 12q15.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500903 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38884
Approved symbol	MIR3913-1
Name	microRNA 3913-1
Location	12q15
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3913-1
Ensembl gene	ENSG00000264405
Ensembl biotype	miRNA
Entrez	100500903
RNAcentral	URS000075D010 — miRNA, 102 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577744

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577744 — 1 exons

Exon	Start	End
ENSE00002714662	69584722	69584823

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 73.72.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right atrium auricular region	UBERON:0006631	73.72	gold quality
monocyte	CL:0000576	71.87	gold quality
blood	UBERON:0000178	70.18	gold quality
omental fat pad	UBERON:0010414	68.88	gold quality
esophagus mucosa	UBERON:0002469	68.17	gold quality
body of stomach	UBERON:0001161	65.83	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.54	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.71	gold quality
hypothalamus	UBERON:0001898	64.24	gold quality
left lobe of thyroid gland	UBERON:0001120	63.04	gold quality
amygdala	UBERON:0001876	56.98	gold quality
prostate gland	UBERON:0002367	56.61	gold quality
left testis	UBERON:0004533	54.57	gold quality
right testis	UBERON:0004534	45.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.