MIR3914-1

Summary

MIR3914-1 (microRNA 3914-1, HGNC:38993) is a microRNA gene on chromosome 7q11.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500836 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38993
Approved symbol	MIR3914-1
Name	microRNA 3914-1
Location	7q11.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3914-1
Ensembl gene	ENSG00000265878
Ensembl biotype	miRNA
Entrez	100500836
RNAcentral	URS000075A34C — miRNA, 99 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584357

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584357 — 1 exons

Exon	Start	End
ENSE00002708559	71307672	71307770

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 96.05.

Top tissues by expression

45 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.05	gold quality
monocyte	CL:0000576	81.67	gold quality
endometrium	UBERON:0001295	76.29	gold quality
blood	UBERON:0000178	74.26	gold quality
stomach	UBERON:0000945	73.37	gold quality
tibial artery	UBERON:0007610	72.61	gold quality
kidney	UBERON:0002113	71.83	gold quality
ascending aorta	UBERON:0001496	71.59	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.14	gold quality
putamen	UBERON:0001874	70.85	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.75	gold quality
calcaneal tendon	UBERON:0003701	69.63	gold quality
nucleus accumbens	UBERON:0001882	69.57	gold quality
heart	UBERON:0000948	69.55	gold quality
vagina	UBERON:0000996	69.36	gold quality
omental fat pad	UBERON:0010414	68.96	gold quality
anterior cingulate cortex	UBERON:0009835	68.74	gold quality
lung	UBERON:0002048	68.52	gold quality
hypothalamus	UBERON:0001898	67.53	gold quality
tibial nerve	UBERON:0001323	67.49	gold quality
intestine	UBERON:0000160	67.09	gold quality
colon	UBERON:0001155	67.00	gold quality
right adrenal gland	UBERON:0001233	66.60	gold quality
left adrenal gland	UBERON:0001234	66.44	gold quality
myometrium	UBERON:0001296	66.29	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.68	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.67	gold quality
corpus callosum	UBERON:0002336	65.52	gold quality
Ammon’s horn	UBERON:0001954	65.43	gold quality
right frontal lobe	UBERON:0002810	64.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.40

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Overexpression of miR-1306-5p, miR-3195, and miR-3914 Inhibits Ameloblast Differentiation through Suppression of Genes Associated with Human Amelogenesis Imperfecta. (PMID:33672174)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.