MIR3915

Summary

MIR3915 (microRNA 3915, HGNC:38955) is a microRNA gene on chromosome Xp21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500915 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38955
Approved symbol	MIR3915
Name	microRNA 3915
Location	Xp21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3915
Ensembl gene	ENSG00000263600
Ensembl biotype	miRNA
Entrez	100500915
RNAcentral	URS000075ADC0 — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578518

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578518 — 1 exons

Exon	Start	End
ENSE00002710287	32583656	32583752

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 78.18.

Top tissues by expression

45 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	78.18	gold quality
stomach	UBERON:0000945	74.48	gold quality
gastrocnemius	UBERON:0001388	73.04	gold quality
adrenal tissue	UBERON:0018303	72.90	gold quality
heart	UBERON:0000948	71.67	gold quality
right atrium auricular region	UBERON:0006631	70.26	gold quality
ascending aorta	UBERON:0001496	69.87	gold quality
lung	UBERON:0002048	69.76	gold quality
substantia nigra	UBERON:0002038	69.62	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.24	gold quality
tibial artery	UBERON:0007610	69.03	gold quality
heart left ventricle	UBERON:0002084	68.38	gold quality
myometrium	UBERON:0001296	67.63	gold quality
upper lobe of left lung	UBERON:0008952	67.62	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.52	gold quality
vagina	UBERON:0000996	66.73	gold quality
left coronary artery	UBERON:0001626	66.70	gold quality
left ovary	UBERON:0002119	66.70	gold quality
body of stomach	UBERON:0001161	66.63	gold quality
colon	UBERON:0001155	66.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.38	gold quality
prostate gland	UBERON:0002367	66.29	gold quality
putamen	UBERON:0001874	65.95	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.75	gold quality
transverse colon	UBERON:0001157	65.70	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.15	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.94	gold quality
right ovary	UBERON:0002118	64.92	gold quality
skin of abdomen	UBERON:0001416	64.73	gold quality
right frontal lobe	UBERON:0002810	64.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.