MIR3916

Summary

MIR3916 (microRNA 3916, HGNC:38912) is a microRNA gene on chromosome 1q44.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500849 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38912
Approved symbol	MIR3916
Name	microRNA 3916
Location	1q44
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3916
Ensembl gene	ENSG00000283881
Ensembl biotype	miRNA
Entrez	100500849
RNAcentral	URS000075ECB1 — miRNA, 94 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000640589

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000640589 — 1 exons

Exon	Start	End
ENSE00003805825	247201967	247202060

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 82.29.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3873 / max 162.8225, expressed in 157 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
18503	0.3873	157

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	82.29	gold quality
tibial nerve	UBERON:0001323	79.49	gold quality
lung	UBERON:0002048	78.69	gold quality
intestine	UBERON:0000160	77.06	gold quality
subcutaneous adipose tissue	UBERON:0002190	76.00	gold quality
blood	UBERON:0000178	73.57	gold quality
heart	UBERON:0000948	73.33	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.14	gold quality
skin of abdomen	UBERON:0001416	72.82	gold quality
body of stomach	UBERON:0001161	71.07	gold quality
stomach	UBERON:0000945	70.01	gold quality
heart left ventricle	UBERON:0002084	69.83	gold quality
muscle of leg	UBERON:0001383	68.44	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.79	gold quality
gastrocnemius	UBERON:0001388	67.50	gold quality
putamen	UBERON:0001874	67.25	gold quality
adult mammalian kidney	UBERON:0000082	67.05	gold quality
skin of leg	UBERON:0001511	66.76	gold quality
nucleus accumbens	UBERON:0001882	66.49	gold quality
Ammon’s horn	UBERON:0001954	65.19	gold quality
liver	UBERON:0002107	63.99	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.01	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.52	gold quality
islet of Langerhans	UBERON:0000006	62.13	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.50	gold quality
caudate nucleus	UBERON:0001873	59.94	gold quality
hypothalamus	UBERON:0001898	59.77	gold quality
anterior cingulate cortex	UBERON:0009835	56.96	gold quality
cerebellar hemisphere	UBERON:0002245	54.33	gold quality
amygdala	UBERON:0001876	39.75	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.